SGCB protein (Felis catus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SGCB

Sarcoglycan beta. (342 aa)

Predicted Functional Partners:

SGCD

0.780

SGCA

0.759

SGCG

0.754

SGCZ

0.750

SGCE

0.718

DAG1

0.707

SNTB1

0.652

SNTA1

0.630

SNTB2

0.630

SNTG2

0.615

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAG1	SGCA	ENSFCAP00000049401	ENSFCAP00000004212	Peptidase S72 domain-containing protein.	Sarcoglycan alpha.	0.908
DAG1	SGCB	ENSFCAP00000049401	ENSFCAP00000052275	Peptidase S72 domain-containing protein.	Sarcoglycan beta.	0.707
DAG1	SGCD	ENSFCAP00000049401	ENSFCAP00000035676	Peptidase S72 domain-containing protein.	Sarcoglycan delta.	0.915
DAG1	SGCE	ENSFCAP00000049401	ENSFCAP00000021469	Peptidase S72 domain-containing protein.	Sarcoglycan epsilon.	0.691
DAG1	SGCG	ENSFCAP00000049401	ENSFCAP00000046439	Peptidase S72 domain-containing protein.	Sarcoglycan gamma.	0.901
DAG1	SGCZ	ENSFCAP00000049401	ENSFCAP00000025517	Peptidase S72 domain-containing protein.	Sarcoglycan zeta.	0.701
DAG1	SNTA1	ENSFCAP00000049401	ENSFCAP00000021236	Peptidase S72 domain-containing protein.	Syntrophin alpha 1.	0.852
DAG1	SNTB1	ENSFCAP00000049401	ENSFCAP00000051092	Peptidase S72 domain-containing protein.	Syntrophin beta 1.	0.818
DAG1	SNTB2	ENSFCAP00000049401	ENSFCAP00000047909	Peptidase S72 domain-containing protein.	Syntrophin beta 2.	0.761
DAG1	SNTG2	ENSFCAP00000049401	ENSFCAP00000012755	Peptidase S72 domain-containing protein.	Syntrophin gamma 2.	0.731
SGCA	DAG1	ENSFCAP00000004212	ENSFCAP00000049401	Sarcoglycan alpha.	Peptidase S72 domain-containing protein.	0.908
SGCA	SGCB	ENSFCAP00000004212	ENSFCAP00000052275	Sarcoglycan alpha.	Sarcoglycan beta.	0.759
SGCA	SGCD	ENSFCAP00000004212	ENSFCAP00000035676	Sarcoglycan alpha.	Sarcoglycan delta.	0.984
SGCA	SGCE	ENSFCAP00000004212	ENSFCAP00000021469	Sarcoglycan alpha.	Sarcoglycan epsilon.	0.540
SGCA	SGCG	ENSFCAP00000004212	ENSFCAP00000046439	Sarcoglycan alpha.	Sarcoglycan gamma.	0.969
SGCA	SGCZ	ENSFCAP00000004212	ENSFCAP00000025517	Sarcoglycan alpha.	Sarcoglycan zeta.	0.748
SGCA	SNTA1	ENSFCAP00000004212	ENSFCAP00000021236	Sarcoglycan alpha.	Syntrophin alpha 1.	0.877
SGCA	SNTB1	ENSFCAP00000004212	ENSFCAP00000051092	Sarcoglycan alpha.	Syntrophin beta 1.	0.847
SGCA	SNTB2	ENSFCAP00000004212	ENSFCAP00000047909	Sarcoglycan alpha.	Syntrophin beta 2.	0.781
SGCA	SNTG2	ENSFCAP00000004212	ENSFCAP00000012755	Sarcoglycan alpha.	Syntrophin gamma 2.	0.771

page 1 of 6

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0522

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099560

Synaptic membrane adhesion

5 of 12

2.84

4.76

1.30e-09

GO:0035335

Peptidyl-tyrosine dephosphorylation

4 of 27

2.39

2.73

5.75e-06

GO:0019221

Cytokine-mediated signaling pathway

6 of 181

1.74

2.39

1.81e-06

GO:0097374

Sensory neuron axon guidance

2 of 4

2.92

1.36

0.0035

GO:0070498

interleukin-1-mediated signaling pathway

2 of 7

2.68

1.21

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004908

interleukin-1 receptor activity

4 of 4

3.22

4.35

1.23e-08

GO:0061809

NAD+ nucleotidase, cyclic ADP-ribose generating

3 of 15

2.52

2.13

0.00011

GO:0050135

NAD(P)+ nucleosidase activity

3 of 15

2.52

2.13

0.00011

GO:0004725

Protein tyrosine phosphatase activity

4 of 97

1.84

1.86

0.00011

GO:0008201

Heparin binding

4 of 114

1.77

1.75

0.00016

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34025644

(2021) Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.

3 of 39

2.11

1.48

0.0014

PMID:27231948

(2016) The Function of Fish Cytokines.

3 of 40

2.1

1.48

0.0014

PMID:35371107

(2022) Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-gamma in Chinese Sturgeon Macrophages.

2 of 12

2.44

1.16

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

NAD+ nucleosidase activity, and interleukin-1-mediated signaling pathway

6 of 17

2.77

6.02

3.38e-12

CL:4443

interleukin-1-mediated signaling pathway, and Inflammatory response

4 of 5

3.13

4.47

6.78e-09

CL:7095

Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

4 of 21

2.5

3.38

3.39e-07

CL:7097

Synaptic membrane adhesion, and Presynaptic membrane assembly

3 of 13

2.59

2.46

2.65e-05

CL:7099

Synaptic membrane adhesion, and NTF3 activates NTRK3 signaling

2 of 5

2.82

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

4 of 105

1.8

1.9

7.30e-05

map04910

Insulin signaling pathway

4 of 157

1.63

1.68

0.00012

map04620

Toll-like receptor signaling pathway

3 of 91

1.74

1.49

0.00067

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04010

MAPK signaling pathway

5 of 361

1.36

1.41

0.00012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-388844

Receptor-type tyrosine-protein phosphatases

5 of 24

2.54

4.43

2.60e-09

MAP-446652

Interleukin-1 family signaling

7 of 108

2.03

4.21

1.69e-10

MAP-8849932

Synaptic adhesion-like molecules

4 of 21

2.5

3.37

3.63e-07

MAP-6794362

Protein-protein interactions at synapses

5 of 89

1.97

2.89

4.72e-07

MAP-9020702

Interleukin-1 signaling

5 of 95

1.94

2.83

5.39e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 70

1.85

1.25

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004074

Interleukin-1 receptor type I/II

4 of 7

2.98

3.72

1.52e-07

IPR015621

Interleukin-1 receptor family

4 of 10

2.82

3.59

2.31e-07

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

3 of 29

2.24

1.68

0.00065

IPR035897

Toll/interleukin-1 receptor homology (TIR) domain superfamily

3 of 31

2.21

1.65

0.00070

IPR003598

Immunoglobulin subtype 2

5 of 245

1.53

1.52

0.00021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 39

2.11

1.59

0.00085

SM00409

Immunoglobulin

5 of 351

1.38

1.2

0.00085

SM00255

Toll - interleukin 1 - resistance

2 of 14

2.38

1.09

0.0098

SM00408

Immunoglobulin C-2 Type

3 of 206

1.39

0.67

0.0378

SM00060

Fibronectin type 3 domain

3 of 198

1.4

0.67

0.0378

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