STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBR3E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1903 aa)    
Predicted Functional Partners:
HECTD1
HECT domain E3 ubiquitin protein ligase 1.
   
  
 0.824
CUL5
Cullin-5; Belongs to the cullin family.
   
    0.806
PDZD4
Rho GTPase activating protein 4.
      
 0.752
ATMIN
ATM interactor.
      
 0.676
NINL
Ninein like.
   
  
 0.664
KLHL23
Kelch like family member 23.
     
 0.628
USP28
Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family.
   
  
 0.627
WWP1
E3 ubiquitin-protein ligase.
   
  
 0.619
CUL3
Cullin 3; Belongs to the cullin family.
   
  
 0.609
KBTBD12
Kelch repeat and BTB domain containing 12.
   
 
 0.601
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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