LOC101098145 protein (Felis catus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

LOC101098145

Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)

Predicted Functional Partners:

PEX10

0.677

FDX1

0.638

RDH12

0.623

PEX12

0.576

FASN

0.558

PEX14

0.532

PEX5

0.528

PEX5L

0.512

ENSFCAP00000026617

0.509

RDH5

0.502

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFCAP00000026617	LOC101098145	ENSFCAP00000026617	ENSFCAP00000057070	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.509
ENSFCAP00000026617	PEX10	ENSFCAP00000026617	ENSFCAP00000040278	Ubiquitin-like domain-containing protein.	Peroxisomal biogenesis factor 10.	0.602
ENSFCAP00000026617	PEX12	ENSFCAP00000026617	ENSFCAP00000009640	Ubiquitin-like domain-containing protein.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.574
ENSFCAP00000026617	PEX14	ENSFCAP00000026617	ENSFCAP00000029841	Ubiquitin-like domain-containing protein.	Peroxisomal biogenesis factor 14.	0.602
ENSFCAP00000026617	PEX5	ENSFCAP00000026617	ENSFCAP00000000169	Ubiquitin-like domain-containing protein.	Peroxisomal biogenesis factor 5.	0.637
ENSFCAP00000026617	PEX5L	ENSFCAP00000026617	ENSFCAP00000051454	Ubiquitin-like domain-containing protein.	Peroxisomal biogenesis factor 5 like.	0.634
FASN	LOC101098145	ENSFCAP00000010847	ENSFCAP00000057070	Fatty acid synthase.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.558
FASN	RDH12	ENSFCAP00000010847	ENSFCAP00000059069	Fatty acid synthase.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.428
FDX1	LOC101098145	ENSFCAP00000033279	ENSFCAP00000057070	Ferredoxin 1.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.638
FDX1	RDH12	ENSFCAP00000033279	ENSFCAP00000059069	Ferredoxin 1.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.681
LOC101098145	ENSFCAP00000026617	ENSFCAP00000057070	ENSFCAP00000026617	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Ubiquitin-like domain-containing protein.	0.509
LOC101098145	FASN	ENSFCAP00000057070	ENSFCAP00000010847	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Fatty acid synthase.	0.558
LOC101098145	FDX1	ENSFCAP00000057070	ENSFCAP00000033279	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Ferredoxin 1.	0.638
LOC101098145	PEX10	ENSFCAP00000057070	ENSFCAP00000040278	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Peroxisomal biogenesis factor 10.	0.677
LOC101098145	PEX12	ENSFCAP00000057070	ENSFCAP00000009640	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.576
LOC101098145	PEX14	ENSFCAP00000057070	ENSFCAP00000029841	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Peroxisomal biogenesis factor 14.	0.532
LOC101098145	PEX5	ENSFCAP00000057070	ENSFCAP00000000169	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Peroxisomal biogenesis factor 5.	0.528
LOC101098145	PEX5L	ENSFCAP00000057070	ENSFCAP00000051454	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Peroxisomal biogenesis factor 5 like.	0.512
LOC101098145	RDH12	ENSFCAP00000057070	ENSFCAP00000059069	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.623
LOC101098145	RDH5	ENSFCAP00000057070	ENSFCAP00000012945	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.502

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.876

expected number of edges:

18

PPI enrichment p-value:

1.81e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

7 of 42

2.37

5.76

8.57e-13

GO:0006412

Translation

10 of 311

1.65

3.62

5.40e-13

GO:0034660

ncRNA metabolic process

8 of 407

1.44

2.29

9.92e-09

GO:0010467

Gene expression

11 of 1202

1.11

1.55

2.57e-10

GO:0034641

Cellular nitrogen compound metabolic process

11 of 2110

0.86

0.95

7.66e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 41

2.31

4.54

4.47e-10

GO:0002161

aminoacyl-tRNA editing activity

3 of 11

2.58

2.45

2.78e-05

GO:0003735

Structural constituent of ribosome

4 of 165

1.53

1.31

0.00092

GO:0000049

tRNA binding

2 of 41

1.83

0.77

0.0333

GO:0005524

ATP binding

6 of 991

0.93

0.69

0.0043

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017102

Methionyl glutamyl tRNA synthetase complex

3 of 3

3.15

2.94

4.59e-06

GO:0022625

Cytosolic large ribosomal subunit

4 of 47

2.08

2.38

1.47e-05

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

2 of 5

2.75

1.69

0.00083

GO:1990904

Ribonucleoprotein complex

5 of 446

1.2

1.05

0.00079

GO:0005829

Cytosol

8 of 1086

1.01

1.04

2.42e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1309

Selenoamino acid metabolism, and prolyl-tRNA aminoacylation

7 of 12

2.91

7.87

1.11e-15

CL:1313

Methionyl glutamyl tRNA synthetase complex, and prolyl-tRNA aminoacylation

5 of 5

3.15

6.12

5.48e-12

CL:751

Ribosomal protein

3 of 63

1.82

1.23

0.0033

CL:709

Structural constituent of ribosome, and Translation elongation factor activity

4 of 200

1.45

1.1

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfy00970

Aminoacyl-tRNA biosynthesis

6 of 40

2.32

5.06

2.77e-11

pfy03010

Ribosome

4 of 108

1.72

1.89

5.06e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2408522

Selenoamino acid metabolism

7 of 13

2.88

8.12

2.91e-16

MAP-379716

Cytosolic tRNA aminoacylation

7 of 17

2.76

7.74

8.67e-16

MAP-379724

tRNA Aminoacylation

7 of 38

2.41

6.26

8.48e-14

MAP-72766

Translation

11 of 288

1.73

4.5

1.14e-16

MAP-392499

Metabolism of proteins

11 of 1192

1.11

1.58

1.17e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022625

Cytosolic large ribosomal subunit

4 of 42

2.13

2.32

2.29e-05

GOCC:0017102

Methionyl glutamyl tRNA synthetase complex

2 of 2

3.15

1.84

0.00047

GOCC:0005829

Cytosol

6 of 481

1.24

1.25

0.00013

GOCC:0032991

Protein-containing complex

8 of 2761

0.61

0.42

0.0134

GOCC:0005737

Cytoplasm

9 of 4420

0.46

0.3

0.0407

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0436

Ligase

6 of 60

2.15

4.25

5.57e-10

KW-0030

Aminoacyl-tRNA synthetase

4 of 16

2.54

3.7

8.50e-08

KW-0648

Protein biosynthesis

4 of 56

2.0

2.5

5.62e-06

KW-0689

Ribosomal protein

4 of 89

1.8

2.07

2.49e-05

KW-0067

ATP-binding

4 of 357

1.2

0.9

0.0036

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

3.15

1.38

0.0033

PF09334

tRNA synthetases class I (M)

2 of 4

2.85

1.37

0.0033

PF00749

tRNA synthetases class I (E and Q), catalytic domain

2 of 3

2.97

1.37

0.0033

PF08264

Anticodon-binding domain of tRNA ligase

2 of 6

2.67

1.33

0.0038

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

4 of 12

2.67

3.31

6.36e-07

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

5 of 49

2.16

3.03

6.36e-07

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 9

2.67

2.28

6.34e-05

IPR020059

Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain

2 of 2

3.15

1.47

0.0022

IPR020058

Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain

2 of 3

2.97

1.47

0.0022

(more ...)

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