FURIN protein (Felis catus) - STRING interaction network

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FURIN

Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (877 aa)

Predicted Functional Partners:

ACE2

0.885

TMPRSS2

0.877

TGFB1

0.808

MMP11

0.799

PROC

0.784

F2

0.775

F9

0.767

F10

0.767

PDGFA

0.760

PROS1

0.755

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	FURIN	ENSFCAP00000052000	ENSFCAP00000059575	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.885
ACE2	TMPRSS2	ENSFCAP00000052000	ENSFCAP00000007479	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.947
F10	F2	ENSFCAP00000013217	ENSFCAP00000017324	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.988
F10	F9	ENSFCAP00000013217	ENSFCAP00000006767	Coagulation factor X.	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	0.957
F10	FURIN	ENSFCAP00000013217	ENSFCAP00000059575	Coagulation factor X.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.767
F10	PROC	ENSFCAP00000013217	ENSFCAP00000051699	Coagulation factor X.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.653
F2	F10	ENSFCAP00000017324	ENSFCAP00000013217	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.988
F2	F9	ENSFCAP00000017324	ENSFCAP00000006767	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	0.814
F2	FURIN	ENSFCAP00000017324	ENSFCAP00000059575	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.775
F2	PROC	ENSFCAP00000017324	ENSFCAP00000051699	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.957
F9	F10	ENSFCAP00000006767	ENSFCAP00000013217	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	Coagulation factor X.	0.957
F9	F2	ENSFCAP00000006767	ENSFCAP00000017324	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.814
F9	FURIN	ENSFCAP00000006767	ENSFCAP00000059575	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.767
F9	PROC	ENSFCAP00000006767	ENSFCAP00000051699	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.	0.546
FURIN	ACE2	ENSFCAP00000059575	ENSFCAP00000052000	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...]	0.885
FURIN	F10	ENSFCAP00000059575	ENSFCAP00000013217	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Coagulation factor X.	0.767
FURIN	F2	ENSFCAP00000059575	ENSFCAP00000017324	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.775
FURIN	F9	ENSFCAP00000059575	ENSFCAP00000006767	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family.	0.767
FURIN	MMP11	ENSFCAP00000059575	ENSFCAP00000014197	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Matrix metallopeptidase 11.	0.799
FURIN	PDGFA	ENSFCAP00000059575	ENSFCAP00000023057	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.	0.760