TOPBP1 protein (Felis catus) - STRING interaction network

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Score

TOPBP1

DNA topoisomerase II binding protein 1. (1551 aa)

Predicted Functional Partners:

BRCA1

0.993

BRIP1

0.992

BARD1

0.989

CDC45

0.984

RAD9B

0.979

ATRIP

0.979

TP53BP1

0.972

MCM5

0.965

CLSPN

0.961

RHNO1

0.958

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRIP	BARD1	ENSFCAP00000048659	ENSFCAP00000009574	ATR interacting protein.	BRCA1 associated RING domain 1.	0.724
ATRIP	BRCA1	ENSFCAP00000048659	ENSFCAP00000012193	ATR interacting protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.859
ATRIP	BRIP1	ENSFCAP00000048659	ENSFCAP00000015577	ATR interacting protein.	BRCA1 interacting protein C-terminal helicase 1.	0.506
ATRIP	CDC45	ENSFCAP00000048659	ENSFCAP00000036937	ATR interacting protein.	Cell division cycle 45.	0.848
ATRIP	CLSPN	ENSFCAP00000048659	ENSFCAP00000027383	ATR interacting protein.	Claspin.	0.934
ATRIP	MCM5	ENSFCAP00000048659	ENSFCAP00000012838	ATR interacting protein.	Minichromosome maintenance complex component 5; Belongs to the MCM family.	0.652
ATRIP	RAD9B	ENSFCAP00000048659	ENSFCAP00000003814	ATR interacting protein.	RAD9 checkpoint clamp component B.	0.670
ATRIP	RHNO1	ENSFCAP00000048659	ENSFCAP00000024042	ATR interacting protein.	RAD9-HUS1-RAD1 interacting nuclear orphan 1.	0.745
ATRIP	TOPBP1	ENSFCAP00000048659	ENSFCAP00000061271	ATR interacting protein.	DNA topoisomerase II binding protein 1.	0.979
BARD1	ATRIP	ENSFCAP00000009574	ENSFCAP00000048659	BRCA1 associated RING domain 1.	ATR interacting protein.	0.724
BARD1	BRCA1	ENSFCAP00000009574	ENSFCAP00000012193	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRIP1	ENSFCAP00000009574	ENSFCAP00000015577	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.926
BARD1	CLSPN	ENSFCAP00000009574	ENSFCAP00000027383	BRCA1 associated RING domain 1.	Claspin.	0.703
BARD1	RAD9B	ENSFCAP00000009574	ENSFCAP00000003814	BRCA1 associated RING domain 1.	RAD9 checkpoint clamp component B.	0.665
BARD1	RHNO1	ENSFCAP00000009574	ENSFCAP00000024042	BRCA1 associated RING domain 1.	RAD9-HUS1-RAD1 interacting nuclear orphan 1.	0.603
BARD1	TOPBP1	ENSFCAP00000009574	ENSFCAP00000061271	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.989
BARD1	TP53BP1	ENSFCAP00000009574	ENSFCAP00000019469	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein 1.	0.832
BRCA1	ATRIP	ENSFCAP00000012193	ENSFCAP00000048659	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR interacting protein.	0.859
BRCA1	BARD1	ENSFCAP00000012193	ENSFCAP00000009574	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BRIP1	ENSFCAP00000012193	ENSFCAP00000015577	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 interacting protein C-terminal helicase 1.	0.987