Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RASGRF2Ras-specific guanine nucleotide-releasing factor 2 isoform X1. (1239 aa)    
Predicted Functional Partners:
PRKACA
CAMP-dependent protein kinase catalytic subunit alpha isoform X1.
    
 0.842
PRKACB
CAMP-dependent protein kinase catalytic subunit beta isoform X1.
    
 0.842
MRAS
Ras-related protein M-Ras isoform X1.
   
 0.820
RRAS2
Ras-related protein R-Ras2 isoform X1.
   
 0.820
RRAS
LOW QUALITY PROTEIN: ras-related protein R-Ras.
   
 0.820
KRAS
GTPase KRas isoform X1.
    
 0.818
GNG10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10.
     
 0.817
PTK2
Protein tyrosine kinase 2.
    
 0.809
GRB2
Growth factor receptor-binding protein 2.
    
 0.806
CALML4
Calmodulin like 4.
    
 0.793
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.