Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)    
Predicted Functional Partners:
H2AX
Histone H2AX.
    
 0.845
MACROH2A2
Core histone macro-H2A.2.
  
 0.842
GSR
Glutathione reductase, mitochondrial.
  
 0.842
MACROH2A1
Core histone macro-H2A.1 isoform X1.
  
 0.842
NDUFS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5.
    
 
 0.821
LOC109253093
Apoptosis regulator BAX isoform X1.
    
 0.820
LOC109253092
Apoptosis regulator BAX.
    
 0.820
AK2
Adenylate kinase 2, mitochondrial isoform X1.
   
 
 0.811
ENDOG
Endonuclease G, mitochondrial.
   
 
 0.778
EXOG
Nuclease EXOG, mitochondrial.
   
 
 0.778
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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