Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase 2-binding protein 1 isoform X1. (1512 aa)    
Predicted Functional Partners:
BRCA1
BRCA1 DNA repair associated.
   
 0.988
RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1.
    
 0.986
BRIP1
LOW QUALITY PROTEIN: Fanconi anemia group J protein.
   
 0.986
ATR
Serine/threonine-protein kinase ATR.
    
 0.984
BARD1
BRCA1-associated RING domain protein 1 isoform X1.
   
 0.982
RAD9A
Cell cycle checkpoint control protein RAD9A isoform X1.
    
 0.982
TICRR
Treslin.
   
 
 0.980
ATRIP
ATR-interacting protein isoform X1.
    
 0.980
CLSPN
Claspin isoform X1.
   
 0.968
ATM
Serine-protein kinase ATM isoform X1.
   
 0.963
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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