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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
XRCC3DNA repair protein XRCC3. (350 aa)    
Predicted Functional Partners:
RAD51C
DNA repair protein RAD51 homolog 3.
  
0.997
RAD51
DNA repair protein RAD51 homolog 1.
  
 
0.977
WRN
Werner syndrome ATP-dependent helicase isoform X1.
  
 0.976
BLM
Bloom syndrome protein isoform X1.
  
 0.956
DMC1
Meiotic recombination protein DMC1/LIM15 homolog isoform X1.
  
0.950
BRCA2
Breast cancer type 2 susceptibility protein isoform X1.
   
 0.941
XRCC2
DNA repair protein XRCC2 isoform X1.
   
 0.919
RAD51B
DNA repair protein RAD51 homolog 2 isoform X1.
    
0.911
RAD51D
DNA repair protein RAD51 homolog 4.
    
 0.900
FBH1
F-box DNA helicase 1 isoform X1.
  
 
 0.868
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.