STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1L1Niemann-Pick C1-like protein 1 isoform X1. (1331 aa)    
Predicted Functional Partners:
NPC2
Epididymal secretory protein E1.
   
 0.913
SREBF2
Sterol regulatory element-binding transcription factor 2.
   
 0.803
SREBF1
Sterol regulatory element-binding transcription factor 1.
   
 0.768
ABCG5
ATP-binding cassette, subfamily G (WHITE), member 5 (sterolin 1).
   
 
 0.742
MYCN
N-myc proto-oncogene protein.
   
 0.736
ABCG8
ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2).
   
 
 0.716
INSIG1
Insulin-induced gene 1 protein.
   
 0.631
INSIG2
Insulin-induced gene 2 protein.
   
 0.631
SCARB1
Scavenger receptor class B member 1 isoform X1.
   
  
 0.621
ABCB11
ATP-binding cassette, subfamily B (MDR/TAP), member 11.
   
 
 0.557
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.