Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
NPC1L1Niemann-Pick C1-like protein 1 isoform X1. (1331 aa)    
Predicted Functional Partners:
NPC2
Epididymal secretory protein E1.
   
 0.932
OSBPL5
Oxysterol-binding protein-related protein 5.
   
 0.806
SREBF2
Sterol regulatory element-binding transcription factor 2.
    
 0.791
ABCG8
ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2).
   
 
 0.770
ABCG5
ATP-binding cassette, subfamily G (WHITE), member 5 (sterolin 1).
   
 
 0.720
SREBF1
Sterol regulatory element-binding transcription factor 1.
    
 0.715
SCARB1
Scavenger receptor class B member 1 isoform X1.
   
  
 0.704
CYP7A1
Cholesterol 7-alpha-monooxygenase.
      
 0.695
CLDN1
Claudin-1.
      
 0.668
HMGCR
3-hydroxy-3-methylglutaryl-Coenzyme A reductase.
   
  
 0.627
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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