Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TLE2TLE family member 2, transcriptional corepressor. (728 aa)    
Predicted Functional Partners:
TCF7
Transcription factor 7.
    
 0.865
TCF7L1
Transcription factor 7 like 1.
    
 0.864
TCF7L2
Transcription factor 7 like 2.
    
 0.864
LEF1
Lymphoid enhancer-binding factor 1 isoform X1.
    
 0.863
HDAC2
Histone deacetylase 2 isoform X1.
    
 0.811
HDAC1
Histone deacetylase 1 isoform X1.
    
 0.811
RBPJ
Recombining binding protein suppressor of hairless isoform X1.
    
 0.806
RBPJL
Recombining binding protein suppressor of hairless-like protein isoform X1.
    
 0.806
TLE1
Transducin-like enhancer protein 1 isoform X1.
   
 0.768
XIAP
E3 ubiquitin-protein ligase XIAP.
    
  0.657
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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