Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
E2F4Transcription factor E2F4 isoform X1. (406 aa)    
Predicted Functional Partners:
RBL2
Retinoblastoma-like protein 2 isoform X1.
   
 0.995
RBL1
Retinoblastoma-like protein 1 isoform X1.
   
 0.994
RB1
Retinoblastoma-associated protein isoform X1.
   
 0.994
TFDP2
Transcription factor Dp-2 isoform X1.
   
 0.994
TFDP1
Transcription factor Dp-1 isoform X1.
   
 0.986
LIN9
Protein lin-9 homolog isoform X1.
    
 0.982
E2F5
Transcription factor E2F5 isoform X1.
   
 0.973
SMAD4
Mothers against decapentaplegic homolog 4 isoform X1.
    
 0.938
CDK2
Cyclin-dependent kinase 2 isoform X1.
   
 0.933
SMAD2
Mothers against decapentaplegic homolog 2 isoform X1.
    
 0.924
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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