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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
REM1RRAD and GEM like GTPase 1. (297 aa)    
Predicted Functional Partners:
FRMPD2
FERM and PDZ domain-containing protein 2 isoform X1.
    
 0.942
ITSN2
Intersectin-2 isoform X1.
   
 0.843
SNTA1
Alpha-1-syntrophin.
      
 0.769
RHO
Rhodopsin.
    
 0.733
ITSN1
Intersectin-1 isoform X1.
    
 0.721
LOC109253466
Guanine nucleotide-binding protein G(s) subunit alpha.
   
 0.668
CCT6B
T-complex protein 1 subunit zeta-2 isoform X1.
   
 0.656
MET
Hepatocyte growth factor receptor isoform X1.
   
 0.614
ENSPPRP00000027164
annotation not available
   
 0.614
RALGDS
Ral guanine nucleotide dissociation stimulator isoform X1.
    
 0.612
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.