Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HEXABeta-hexosaminidase subunit alpha isoform X1. (530 aa)    
Predicted Functional Partners:
HEXB
Beta-hexosaminidase subunit beta.
   
  0.994
GM2A
Ganglioside GM2 activator.
   
 0.968
NEU3
Sialidase-3 isoform X1.
     
 0.956
NAGA
Alpha-N-acetylgalactosaminidase.
  
 
 0.948
B4GALNT1
(N-Acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase.
     
 0.943
GLA
Alpha-galactosidase A isoform X1.
  
 
 0.941
NEU1
Sialidase-1.
  
 0.936
HEXD
Hexosaminidase D isoform X1.
     
 0.933
GLB1
Beta-galactosidase isoform X1.
  
 
 0.932
GNS
N-acetylglucosamine-6-sulfatase.
   
 0.923
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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