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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM25E3 ubiquitin/ISG15 ligase TRIM25 isoform X1. (608 aa)    
Predicted Functional Partners:
DDX58
Probable ATP-dependent RNA helicase DDX58 isoform X1.
   
 0.984
UBE2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1.
   
 0.931
ISG15
Ubiquitin cross-reactive protein.
   
 0.792
IFIH1
Interferon-induced helicase C domain-containing protein 1 isoform X1.
   
 0.749
IRF3
Interferon regulatory factor 3 isoform X1.
   
 0.670
MAVS
Mitochondrial antiviral-signaling protein isoform X1.
   
 0.670
EIF2AK2
Interferon-induced, double-stranded RNA-activated protein kinase isoform X1.
   
 0.634
MX1
Interferon-induced GTP-binding protein Mx1-like.
   
 
 0.616
UBC
Polyubiquitin-C.
   
 0.610
SP1
Transcription factor Sp1.
   
 0.590
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.