Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TRIM25E3 ubiquitin/ISG15 ligase TRIM25 isoform X1. (608 aa)    
Predicted Functional Partners:
DDX58
Probable ATP-dependent RNA helicase DDX58 isoform X1.
   
 0.958
LOC109276952
Tripartite motif-containing protein 47-like isoform X1.
     
  0.710
SP1
Transcription factor Sp1.
   
 0.702
MAVS
Mitochondrial antiviral-signaling protein isoform X1.
   
 0.699
UBE2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1.
   
 0.693
IRF3
Interferon regulatory factor 3 isoform X1.
   
 0.649
IFIH1
Interferon-induced helicase C domain-containing protein 1 isoform X1.
   
 0.642
G3BP2
Ras GTPase-activating protein-binding protein 2 isoform X1.
   
 
 0.619
RASD2
GTP-binding protein Rhes.
    
 0.610
G3BP1
Ras GTPase-activating protein-binding protein 1.
   
 
 0.603
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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