Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1. (266 aa)    
Predicted Functional Partners:
PTGR1
Prostaglandin reductase 1.
   
 0.952
PTGR2
Prostaglandin reductase 2.
   
 0.941
PTGES
Microsomal prostaglandin-E synthase 1.
     
 0.940
PTGES2
Microsomal prostaglandin-E synthase 2.
     
 0.924
PRXL2B
Peroxiredoxin like 2B.
     
 0.916
ZADH2
Prostaglandin reductase 3 isoform X1.
   
 0.899
PTGES3
Prostaglandin E synthase 3 isoform X1.
     
 0.867
ENSPPRP00000027372
annotation not available
     
 0.867
CBR3
Carbonyl reductase [NADPH] 3.
     
 0.792
MGST1
Microsomal glutathione S-transferase 1 isoform X1.
     
 0.785
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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