Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DENND4CDENN domain-containing protein 4C isoform X1. (1957 aa)    
Predicted Functional Partners:
DENND5A
DENN domain-containing protein 5A isoform X1.
    
0.854
DENND5B
DENN domain containing 5B.
    
 
 0.778
RAB10
Ras-related protein Rab-10.
    
 0.619
MADD
MAP kinase-activating death domain protein isoform X1.
    
 
 0.609
YWHAB
14-3-3 protein beta/theta/zeta.
    
   0.603
CHM
Rab proteins geranylgeranyltransferase component A 1.
     
 0.562
MINDY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1/2.
      
 0.556
DENND1A
DENN domain containing 1A.
   
 
 0.532
DENND6A
Protein DENND6A isoform X1.
      
 0.526
DENND1C
DENN domain-containing protein 1C.
    
 
 0.505
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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