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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDH2Cadherin 2, type 1, N-cadherin. (906 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.885
CTNND1
Catenin (cadherin-associated protein), delta 1.
    
 0.808
JUP
Junction plakoglobin.
   
 0.694
ARVCF
Armadillo repeat protein deleted in velo-cardio-facial syndrome isoform X1.
    
 0.649
CDH1
Cadherin 1, type 1, E-cadherin.
    
0.646
CTNNA2
Catenin alpha 2.
    
 0.621
CTNNA2-2
Catenin alpha-2 isoform X1.
    
 0.621
CTNNA1
Catenin alpha-1.
    
 0.621
SNAI2
Zinc finger protein SNAI2 isoform X1.
      
 0.574
ENSPPRP00000025911
annotation not available
    
 0.549
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.