close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYGO1Pygopus homolog 1 isoform X1. (419 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.915
BCL9
B-cell CLL/lymphoma 9 protein isoform X1.
    
 0.867
RBBP5
Retinoblastoma-binding protein 5 isoform X1.
    
 0.829
ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1.
    
 0.817
JUP
Junction plakoglobin.
   
 0.803
MEN1
Menin.
    
  0.766
KMT2C
Histone-lysine N-methyltransferase 2C isoform X1.
   
 0.733
UNC79
Protein unc-79 homolog isoform X1.
    
 0.710
DTX3
Probable E3 ubiquitin-protein ligase DTX3 isoform X1.
    
 0.617
TCF7
Transcription factor 7.
    
 0.616
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.