Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PYGO1Pygopus homolog 1 isoform X1. (419 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.949
JUP
Junction plakoglobin.
   
 0.881
BCL9
B-cell CLL/lymphoma 9 protein isoform X1.
    
 0.871
LEF1
Lymphoid enhancer-binding factor 1 isoform X1.
    
 0.689
ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1.
    
 0.630
TCF7L1
Transcription factor 7 like 1.
    
 0.619
TCF7L2
Transcription factor 7 like 2.
    
 0.619
UNC79
Protein unc-79 homolog isoform X1.
    
 0.579
LDB1
LIM domain-binding protein 1 isoform X1.
    
 
 0.559
LDB2
LIM domain-binding protein 2 isoform X1.
    
 
 0.559
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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