Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ADAM22ADAM metallopeptidase domain 22. (906 aa)    
Predicted Functional Partners:
DLG4
Disks large homolog 4 isoform X1.
   
 0.963
LGI2
Leucine-rich repeat LGI family member 2.
     
 0.941
ADAM23
Disintegrin and metalloproteinase domain-containing protein 23 isoform X1.
   
 0.829
LGI4
Leucine-rich repeat LGI family member 4 isoform X1.
     
 0.738
CACNG2
Voltage-dependent calcium channel gamma-2 subunit.
   
 
 0.725
SYNGAP1
Ras/Rap GTPase-activating protein SynGAP.
   
 
 0.710
LGI3
Leucine-rich repeat LGI family member 3.
   
 
 0.686
LGI1
Leucine-rich glioma-inactivated protein 1 isoform X1.
     
 0.664
ENSPPRP00000004233
annotation not available
    
   0.652
ENSPPRP00000004694
annotation not available
    
   0.652
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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