Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TFEBTranscription factor EB isoform X1. (549 aa)    
Predicted Functional Partners:
MITF
Microphthalmia-associated transcription factor isoform X1.
   
 0.947
TFE3
Transcription factor E3 isoform X1.
   
 0.939
MTOR
Serine/threonine-protein kinase mTOR.
   
 
 0.934
PPP3CB
Protein phosphatase 3 catalytic subunit beta.
   
 0.917
PPP3CC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1.
   
 0.908
PPP3CA
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1.
   
 0.908
PPP3R1
Serine/threonine-protein phosphatase 2B regulatory subunit.
     
 0.905
RRAGC
Ras-related GTP-binding protein C/D.
    
 
 0.846
YWHAE
14-3-3 protein epsilon isoform X1.
    
 0.814
ULK1
Unc-51 like autophagy activating kinase 1.
      
 0.796
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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