STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-binding protein 2.
    
 0.999
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 isoform X1.
    
 0.994
MET
Hepatocyte growth factor receptor isoform X1.
    
 0.992
EGFR
Epidermal growth factor receptor isoform X1.
   
 0.991
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.
    
 0.990
CRKL
Proto-oncogene C-crk.
    
 0.988
CRK
Adapter molecule crk isoform X1.
    
 0.986
SOS1
Son of sevenless homolog 1 isoform X1.
    
 0.980
SHC1
SHC-transforming protein 1 isoform X1.
    
 0.974
PIK3R2
Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta.
    
 0.974
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.