STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF168E3 ubiquitin-protein ligase RNF168. (565 aa)    
Predicted Functional Partners:
PIAS4
E3 SUMO-protein ligase PIAS4 isoform X1.
     
 0.830
TP53BP1
Tumor suppressor p53-binding protein 1 isoform X1.
    
 0.810
BRCA1
BRCA1 DNA repair associated.
    
 0.809
UBC
Polyubiquitin-C.
    
 0.801
H2AX
Histone H2AX.
    
 0.800
ENSPPRP00000002323
annotation not available
   
 0.776
BARD1
BRCA1-associated RING domain protein 1 isoform X1.
    
 0.736
ENSPPRP00000003910
annotation not available
     
 0.719
RNF8
E3 ubiquitin-protein ligase RNF8 isoform X1.
     
 0.719
CUL3
Cullin-3 isoform X1.
   
 0.715
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.