STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FEN1Flap endonuclease 1. (380 aa)    
Predicted Functional Partners:
WRN
Werner syndrome ATP-dependent helicase isoform X1.
  
 0.998
PCNA
Proliferating cell nuclear antigen.
   
 0.997
POLD1
DNA polymerase delta catalytic subunit.
   
 0.985
LIG1
DNA ligase 1.
  
 0.981
APEX1
DNA-(apurinic or apyrimidinic site) lyase.
   
 0.972
MRE11
Double-strand break repair protein MRE11A isoform X1.
   
 0.965
DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1.
   
 0.963
POLD2
DNA polymerase delta subunit 2.
   
 0.952
POLB
DNA polymerase beta isoform X1.
   
 0.938
ENSPPRP00000012218
annotation not available
   
 0.938
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.