STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFN14-3-3 protein sigma. (248 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53.
   
 0.956
CDK1
Cyclin-dependent kinase 1.
   
 0.941
CCNB1
G2/mitotic-specific cyclin-B1.
    
 0.933
CCNB2
G2/mitotic-specific cyclin-B2 isoform X1.
    
 0.933
CCNB3
G2/mitotic-specific cyclin-B3 isoform X1.
    
 0.927
LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2.
   
 0.897
MDM2
E3 ubiquitin-protein ligase Mdm2 isoform X1.
    
 0.891
MDM4
Protein Mdm4.
    
 0.873
ESR1
Estrogen receptor isoform X1.
    
 
 0.832
AMOT
Angiomotin.
    
 0.813
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.