NUP98 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NUP98

Nuclear pore complex protein Nup98-Nup96 isoform X1. (1800 aa)

Predicted Functional Partners:

SEC13

0.999

NUP37

0.999

RANBP2

0.998

NUP133

0.998

NUP107

0.998

SEH1L

0.998

NUP85

0.998

RAE1

0.997

LOC101367436

0.997

NUP160

0.996

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101367436	NUP107	A0A2U3ZYK3	A0A2U3WC34	LOW QUALITY PROTEIN: mRNA export factor-like.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.775
LOC101367436	NUP133	A0A2U3ZYK3	A0A2U3W9C9	LOW QUALITY PROTEIN: mRNA export factor-like.	Nuclear pore complex protein Nup133.	0.704
LOC101367436	NUP160	A0A2U3ZYK3	A0A2U3VVU8	LOW QUALITY PROTEIN: mRNA export factor-like.	Nuclear pore complex protein Nup160.	0.618
LOC101367436	NUP37	A0A2U3ZYK3	A0A2U3WUV0	LOW QUALITY PROTEIN: mRNA export factor-like.	Nucleoporin Nup37 isoform X1.	0.535
LOC101367436	NUP85	A0A2U3ZYK3	A0A2U3Z9S2	LOW QUALITY PROTEIN: mRNA export factor-like.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.877
LOC101367436	NUP98	A0A2U3ZYK3	A0A2U3VBA7	LOW QUALITY PROTEIN: mRNA export factor-like.	Nuclear pore complex protein Nup98-Nup96 isoform X1.	0.997
LOC101367436	RAE1	A0A2U3ZYK3	A0A2U3X372	LOW QUALITY PROTEIN: mRNA export factor-like.	mRNA export factor.	0.900
LOC101367436	RANBP2	A0A2U3ZYK3	A0A2U3VT13	LOW QUALITY PROTEIN: mRNA export factor-like.	E3 SUMO-protein ligase RanBP2 isoform X1.	0.869
LOC101367436	SEC13	A0A2U3ZYK3	A0A2U3VDN7	LOW QUALITY PROTEIN: mRNA export factor-like.	Protein SEC13 homolog isoform X1; Belongs to the WD repeat SEC13 family.	0.707
LOC101367436	SEH1L	A0A2U3ZYK3	A0A2U3WIA5	LOW QUALITY PROTEIN: mRNA export factor-like.	Nucleoporin SEH1 isoform X1; Belongs to the WD repeat SEC13 family.	0.766
NUP107	LOC101367436	A0A2U3WC34	A0A2U3ZYK3	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	LOW QUALITY PROTEIN: mRNA export factor-like.	0.775
NUP107	NUP133	A0A2U3WC34	A0A2U3W9C9	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nuclear pore complex protein Nup133.	0.999
NUP107	NUP160	A0A2U3WC34	A0A2U3VVU8	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nuclear pore complex protein Nup160.	0.999
NUP107	NUP37	A0A2U3WC34	A0A2U3WUV0	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin Nup37 isoform X1.	0.999
NUP107	NUP85	A0A2U3WC34	A0A2U3Z9S2	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.999
NUP107	NUP98	A0A2U3WC34	A0A2U3VBA7	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nuclear pore complex protein Nup98-Nup96 isoform X1.	0.998
NUP107	RAE1	A0A2U3WC34	A0A2U3X372	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	mRNA export factor.	0.775
NUP107	RANBP2	A0A2U3WC34	A0A2U3VT13	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	E3 SUMO-protein ligase RanBP2 isoform X1.	0.997
NUP107	SEC13	A0A2U3WC34	A0A2U3VDN7	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Protein SEC13 homolog isoform X1; Belongs to the WD repeat SEC13 family.	0.998
NUP107	SEH1L	A0A2U3WC34	A0A2U3WIA5	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	Nucleoporin SEH1 isoform X1; Belongs to the WD repeat SEC13 family.	0.999

page 1 of 6

Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About