node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRB3 | CIDEA | A0A2U3VI07 | A0A2U3WKS2 | Beta-3 adrenergic receptor. | Cell death activator CIDE-A. | 0.622 |
ADRB3 | LEP | A0A2U3VI07 | A0A2U3VS59 | Beta-3 adrenergic receptor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.481 |
ADRB3 | PLIN1 | A0A2U3VI07 | A0A2U3VSX6 | Beta-3 adrenergic receptor. | Perilipin; Belongs to the perilipin family. | 0.540 |
ADRB3 | PPARG | A0A2U3VI07 | A0A2U3VLH3 | Beta-3 adrenergic receptor. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.546 |
ADRB3 | UCP2 | A0A2U3VI07 | A0A2U3VBF6 | Beta-3 adrenergic receptor. | Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.491 |
CIDEA | ADRB3 | A0A2U3WKS2 | A0A2U3VI07 | Cell death activator CIDE-A. | Beta-3 adrenergic receptor. | 0.622 |
CIDEA | LEP | A0A2U3WKS2 | A0A2U3VS59 | Cell death activator CIDE-A. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.487 |
CIDEA | PLIN1 | A0A2U3WKS2 | A0A2U3VSX6 | Cell death activator CIDE-A. | Perilipin; Belongs to the perilipin family. | 0.676 |
CIDEA | PPARA | A0A2U3WKS2 | A0A2U3X1E5 | Cell death activator CIDE-A. | Peroxisome proliferator-activated receptor alpha. | 0.526 |
CIDEA | PPARG | A0A2U3WKS2 | A0A2U3VLH3 | Cell death activator CIDE-A. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.620 |
CIDEA | UCP2 | A0A2U3WKS2 | A0A2U3VBF6 | Cell death activator CIDE-A. | Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.489 |
CPT1A | PPARA | A0A2U3VGV6 | A0A2U3X1E5 | Carnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. | Peroxisome proliferator-activated receptor alpha. | 0.638 |
CPT1A | PPARG | A0A2U3VGV6 | A0A2U3VLH3 | Carnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.684 |
CPT1A | UCP2 | A0A2U3VGV6 | A0A2U3VBF6 | Carnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. | Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.558 |
CPT1A | VTN | A0A2U3VGV6 | A0A2U3X640 | Carnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. | LOW QUALITY PROTEIN: vitronectin. | 0.416 |
LEP | ADRB3 | A0A2U3VS59 | A0A2U3VI07 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Beta-3 adrenergic receptor. | 0.481 |
LEP | CIDEA | A0A2U3VS59 | A0A2U3WKS2 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Cell death activator CIDE-A. | 0.487 |
LEP | NPY | A0A2U3VS59 | A0A2U3VQE0 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Pro-neuropeptide Y. | 0.999 |
LEP | PLIN1 | A0A2U3VS59 | A0A2U3VSX6 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Perilipin; Belongs to the perilipin family. | 0.647 |
LEP | PPARA | A0A2U3VS59 | A0A2U3X1E5 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Peroxisome proliferator-activated receptor alpha. | 0.560 |