FBXO45 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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Score

FBXO45

F-box/SPRY domain-containing protein 1. (285 aa)

Predicted Functional Partners:

MYCBP2

0.937

SPRYD3

0.923

LOC101374307

0.902

SKP1

0.902

KCTD6

0.874

CUL1

0.771

CIT

0.760

TCEB1

0.721

CUL3

0.721

MRPL3

0.680

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIT	FBXO45	A0A2U3VP02	A0A2U3VBP4	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	F-box/SPRY domain-containing protein 1.	0.760
CIT	KCTD6	A0A2U3VP02	A0A2U3ZSX1	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	BTB/POZ domain-containing protein KCTD6 isoform X1.	0.976
CIT	SPRYD3	A0A2U3VP02	A0A2U3WCS5	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	SPRY domain-containing protein 3.	0.966
CUL1	CUL3	A0A2U3WJA3	A0A2U3WFR0	Cullin-1; Belongs to the cullin family.	Cullin-3 isoform X1; Belongs to the cullin family.	0.764
CUL1	FBXO45	A0A2U3WJA3	A0A2U3VBP4	Cullin-1; Belongs to the cullin family.	F-box/SPRY domain-containing protein 1.	0.771
CUL1	LOC101374307	A0A2U3WJA3	A0A2U3W056	Cullin-1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.999
CUL1	SKP1	A0A2U3WJA3	A0A2U3ZKR6	Cullin-1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.999
CUL1	TCEB1	A0A2U3WJA3	A0A2U3W6X4	Cullin-1; Belongs to the cullin family.	Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family.	0.763
CUL3	CUL1	A0A2U3WFR0	A0A2U3WJA3	Cullin-3 isoform X1; Belongs to the cullin family.	Cullin-1; Belongs to the cullin family.	0.764
CUL3	FBXO45	A0A2U3WFR0	A0A2U3VBP4	Cullin-3 isoform X1; Belongs to the cullin family.	F-box/SPRY domain-containing protein 1.	0.721
CUL3	KCTD6	A0A2U3WFR0	A0A2U3ZSX1	Cullin-3 isoform X1; Belongs to the cullin family.	BTB/POZ domain-containing protein KCTD6 isoform X1.	0.876
CUL3	LOC101374307	A0A2U3WFR0	A0A2U3W056	Cullin-3 isoform X1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.890
CUL3	SKP1	A0A2U3WFR0	A0A2U3ZKR6	Cullin-3 isoform X1; Belongs to the cullin family.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.890
CUL3	SPRYD3	A0A2U3WFR0	A0A2U3WCS5	Cullin-3 isoform X1; Belongs to the cullin family.	SPRY domain-containing protein 3.	0.627
CUL3	TCEB1	A0A2U3WFR0	A0A2U3W6X4	Cullin-3 isoform X1; Belongs to the cullin family.	Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family.	0.755
FBXO45	CIT	A0A2U3VBP4	A0A2U3VP02	F-box/SPRY domain-containing protein 1.	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.760
FBXO45	CUL1	A0A2U3VBP4	A0A2U3WJA3	F-box/SPRY domain-containing protein 1.	Cullin-1; Belongs to the cullin family.	0.771
FBXO45	CUL3	A0A2U3VBP4	A0A2U3WFR0	F-box/SPRY domain-containing protein 1.	Cullin-3 isoform X1; Belongs to the cullin family.	0.721
FBXO45	KCTD6	A0A2U3VBP4	A0A2U3ZSX1	F-box/SPRY domain-containing protein 1.	BTB/POZ domain-containing protein KCTD6 isoform X1.	0.874
FBXO45	LOC101374307	A0A2U3VBP4	A0A2U3W056	F-box/SPRY domain-containing protein 1.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.902

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Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.817

expected number of edges:

11

PPI enrichment p-value:

4.89e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019363

Pyridine nucleotide biosynthetic process

7 of 15

2.2

4.82

3.07e-11

GO:0019359

Nicotinamide nucleotide biosynthetic process

6 of 14

2.16

4.23

7.46e-10

GO:0009435

NAD biosynthetic process

5 of 12

2.15

3.54

3.73e-08

GO:0009165

Nucleotide biosynthetic process

8 of 77

1.55

2.73

1.11e-09

GO:0009117

Nucleotide metabolic process

9 of 111

1.44

2.49

3.08e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004514

Nicotinate-nucleotide diphosphorylase (carboxylating) activity

3 of 3

2.53

1.95

0.00024

GO:0004516

Nicotinate phosphoribosyltransferase activity

2 of 2

2.53

1.1

0.0099

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 40

1.41

0.69

0.0346

GO:0016740

Transferase activity

7 of 544

0.64

0.39

0.0346

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1020

0.48

0.32

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1329

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

10 of 29

2.07

6.28

3.84e-17

CL:1330

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

9 of 22

2.14

6.17

1.14e-15

CL:1333

Nicotinate and nicotinamide metabolism

6 of 6

2.53

5.39

2.31e-11

CL:1331

Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

7 of 16

2.17

4.93

1.08e-11

CL:1362

Mixed, incl. GDP metabolic process, and Cytidyltransferase-like domain

2 of 6

2.06

0.77

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00760

Nicotinate and nicotinamide metabolism

10 of 15

2.36

8.53

2.54e-20

mtt01100

Metabolic pathways

10 of 566

0.78

0.77

3.44e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

4 of 45

1.48

1.2

0.0016

KW-0328

Glycosyltransferase

3 of 27

1.58

1.01

0.0072

KW-0662

Pyridine nucleotide biosynthesis

2 of 7

1.99

0.92

0.0184

KW-0547

Nucleotide-binding

5 of 286

0.78

0.45

0.0349

KW-0808

Transferase

6 of 436

0.67

0.4

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04095

Nicotinate phosphoribosyltransferase (NAPRTase) family

2 of 2

2.53

0.88

0.0248

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036068

Nicotinate phosphoribosyltransferase-like, C-terminal

3 of 3

2.53

1.79

0.00049

IPR041525

Nicotinate/nicotinamide phosphoribosyltransferase

2 of 2

2.53

0.83

0.0310

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