ZNF469 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ZNF469

Zinc finger protein 469. (3763 aa)

Predicted Functional Partners:

VSX1

0.620

FNDC3B

0.528

SORBS3

0.521

RIT1

0.492

UCK2

0.487

RIPK4

0.483

ADGRA3

0.474

ANKRD24

0.463

SPDYC

0.461

CTDSP2

0.460

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRA3	CTDSP2	A0A2U3ZIA1	A0A2U3W1M4	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	0.614
ADGRA3	RIT1	A0A2U3ZIA1	A0A2U3W4G4	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	GTP-binding protein Rit1.	0.657
ADGRA3	SPDYC	A0A2U3ZIA1	A0A2U3VGX0	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	Speedy protein C.	0.622
ADGRA3	ZNF469	A0A2U3ZIA1	A0A2U3VCC9	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	Zinc finger protein 469.	0.474
ANKRD24	ZNF469	A0A2U3ZAX5	A0A2U3VCC9	Ankyrin repeat domain-containing protein 24.	Zinc finger protein 469.	0.463
CTDSP2	ADGRA3	A0A2U3W1M4	A0A2U3ZIA1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	0.614
CTDSP2	RIT1	A0A2U3W1M4	A0A2U3W4G4	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	GTP-binding protein Rit1.	0.595
CTDSP2	SPDYC	A0A2U3W1M4	A0A2U3VGX0	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	Speedy protein C.	0.531
CTDSP2	ZNF469	A0A2U3W1M4	A0A2U3VCC9	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	Zinc finger protein 469.	0.460
FNDC3B	VSX1	A0A2U3VFJ2	A0A2U3VT72	Fibronectin type III domain-containing protein 3B.	Visual system homeobox 1.	0.455
FNDC3B	ZNF469	A0A2U3VFJ2	A0A2U3VCC9	Fibronectin type III domain-containing protein 3B.	Zinc finger protein 469.	0.528
RIPK4	RIT1	A0A2U3WDJ0	A0A2U3W4G4	Receptor-interacting serine/threonine-protein kinase 4.	GTP-binding protein Rit1.	0.449
RIPK4	UCK2	A0A2U3WDJ0	A0A2U3WI00	Receptor-interacting serine/threonine-protein kinase 4.	Uridine-cytidine kinase; Belongs to the uridine kinase family.	0.437
RIPK4	ZNF469	A0A2U3WDJ0	A0A2U3VCC9	Receptor-interacting serine/threonine-protein kinase 4.	Zinc finger protein 469.	0.483
RIT1	ADGRA3	A0A2U3W4G4	A0A2U3ZIA1	GTP-binding protein Rit1.	Probable G-protein coupled receptor 125; Belongs to the G-protein coupled receptor 2 family.	0.657
RIT1	CTDSP2	A0A2U3W4G4	A0A2U3W1M4	GTP-binding protein Rit1.	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2.	0.595
RIT1	RIPK4	A0A2U3W4G4	A0A2U3WDJ0	GTP-binding protein Rit1.	Receptor-interacting serine/threonine-protein kinase 4.	0.449
RIT1	SPDYC	A0A2U3W4G4	A0A2U3VGX0	GTP-binding protein Rit1.	Speedy protein C.	0.611
RIT1	ZNF469	A0A2U3W4G4	A0A2U3VCC9	GTP-binding protein Rit1.	Zinc finger protein 469.	0.492
SORBS3	ZNF469	A0A2U3W2K6	A0A2U3VCC9	Vinexin.	Zinc finger protein 469.	0.521

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.825

expected number of edges:

15

PPI enrichment p-value:

0.00198

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009432

SOS response

4 of 11

1.79

1.5

0.00075

GO:0006260

DNA replication

5 of 38

1.35

1.19

0.00083

GO:0006281

DNA repair

5 of 44

1.29

1.13

0.00083

GO:0006259

DNA metabolic process

7 of 128

0.97

0.83

0.00083

GO:0051301

Cell division

3 of 22

1.37

0.78

0.0179

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015648

Lipid-linked peptidoglycan transporter activity

3 of 4

2.11

1.37

0.0024

GO:0003887

DNA-directed DNA polymerase activity

3 of 8

1.81

1.27

0.0027

GO:0140097

Catalytic activity, acting on DNA

5 of 73

1.07

0.83

0.0027

GO:0003684

Damaged DNA binding

2 of 6

1.76

0.73

0.0388

GO:0004252

Serine-type endopeptidase activity

2 of 8

1.63

0.67

0.0487

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. DNA replication, and Nucleotide excision repair

4 of 29

1.37

0.88

0.0096

CL:558

Mixed, incl. Nucleotide excision repair, and Mre11 nuclease, N-terminal metallophosphatase domain

3 of 18

1.46

0.75

0.0253

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

3 of 14

1.56

0.96

0.0091

map03430

Mismatch repair

3 of 27

1.28

0.69

0.0261

map03440

Homologous recombination

3 of 31

1.22

0.67

0.0261

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 5

2.01

1.43

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

3 of 14

1.56

0.9

0.0130

KW-0239

DNA-directed DNA polymerase

2 of 5

1.84

0.88

0.0196

KW-0234

DNA repair

3 of 23

1.35

0.77

0.0181

KW-0227

DNA damage

3 of 23

1.35

0.77

0.0181

KW-0742

SOS response

2 of 8

1.63

0.73

0.0346

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01098

Cell cycle protein

3 of 3

2.23

1.62

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

3 of 3

2.23

1.39

0.0024

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