NPR2 protein (Odobenus rosmarus) - STRING interaction network

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Score

NPR2

Guanylate cyclase. (1047 aa)

Predicted Functional Partners:

NPPC

0.999

NPPA

0.993

NPR1

0.916

ITPA

0.908

NUDT2

0.904

PDE5A

0.865

PDE2A

0.835

LOC105757534

0.828

PDE3A

0.828

GCH1

0.818

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GCH1	ITPA	A0A2U3W9F9	A0A2U3VSH9	GTP cyclohydrolase 1 isoform X1.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.946
GCH1	NPR1	A0A2U3W9F9	A0A2U3W4P9	GTP cyclohydrolase 1 isoform X1.	Guanylate cyclase.	0.812
GCH1	NPR2	A0A2U3W9F9	A0A2U3VCL8	GTP cyclohydrolase 1 isoform X1.	Guanylate cyclase.	0.818
GCH1	NUDT2	A0A2U3W9F9	A0A2U3ZGQ9	GTP cyclohydrolase 1 isoform X1.	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical].	0.888
ITPA	GCH1	A0A2U3VSH9	A0A2U3W9F9	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	GTP cyclohydrolase 1 isoform X1.	0.946
ITPA	LOC105757534	A0A2U3VSH9	A0A2U3ZIX3	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.900
ITPA	NPR1	A0A2U3VSH9	A0A2U3W4P9	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Guanylate cyclase.	0.909
ITPA	NPR2	A0A2U3VSH9	A0A2U3VCL8	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Guanylate cyclase.	0.908
ITPA	NUDT2	A0A2U3VSH9	A0A2U3ZGQ9	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical].	0.956
ITPA	PDE2A	A0A2U3VSH9	A0A2U3VBT8	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.913
ITPA	PDE3A	A0A2U3VSH9	A0A2U3ZX33	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.900
ITPA	PDE5A	A0A2U3VSH9	A0A2U3W173	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Phosphodiesterase.	0.911
LOC105757534	ITPA	A0A2U3ZIX3	A0A2U3VSH9	Phosphodiesterase.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.900
LOC105757534	NPPC	A0A2U3ZIX3	A0A2U3VM47	Phosphodiesterase.	C-type natriuretic peptide.	0.528
LOC105757534	NPR1	A0A2U3ZIX3	A0A2U3W4P9	Phosphodiesterase.	Guanylate cyclase.	0.716
LOC105757534	NPR2	A0A2U3ZIX3	A0A2U3VCL8	Phosphodiesterase.	Guanylate cyclase.	0.828
LOC105757534	PDE3A	A0A2U3ZIX3	A0A2U3ZX33	Phosphodiesterase.	Phosphodiesterase.	0.900
NPPA	NPPC	A0A2U3WPW1	A0A2U3VM47	Natriuretic peptides A.	C-type natriuretic peptide.	0.845
NPPA	NPR1	A0A2U3WPW1	A0A2U3W4P9	Natriuretic peptides A.	Guanylate cyclase.	0.994
NPPA	NPR2	A0A2U3WPW1	A0A2U3VCL8	Natriuretic peptides A.	Guanylate cyclase.	0.993