LOC101378315 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

LOC101378315

Bcl10-interacting CARD protein isoform X1. (183 aa)

Predicted Functional Partners:

ABTB1

0.723

SLC9C2

0.713

SLC22A12

0.711

MEGF8

0.695

PCYOX1

0.641

ASB5

0.621

ECI2

0.613

NDUFS5

0.523

GALP

0.523

LOC101384994

0.522

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABTB1	ASB5	A0A2U3VLD7	A0A2U3WDB7	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 5.	0.621
ABTB1	ECI2	A0A2U3VLD7	A0A2U3WXS2	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	enoyl-CoA delta isomerase 2, mitochondrial.	0.538
ABTB1	GALP	A0A2U3VLD7	A0A2U3W9X8	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	Galanin-like peptide.	0.523
ABTB1	LOC101378315	A0A2U3VLD7	A0A2U3VFX0	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	Bcl10-interacting CARD protein isoform X1.	0.723
ABTB1	MEGF8	A0A2U3VLD7	A0A2U3WHI3	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8.	0.627
ABTB1	NDUFS5	A0A2U3VLD7	A0A2U3W3M9	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5.	0.451
ABTB1	PCYOX1	A0A2U3VLD7	A0A2U3VTM5	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	Prenylcysteine oxidase 1 isoform X1.	0.642
ABTB1	SLC22A12	A0A2U3VLD7	A0A2U3VGZ8	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	Solute carrier family 22 member 12.	0.529
ABTB1	SLC9C2	A0A2U3VLD7	A0A2U3ZPN9	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	Sodium/hydrogen exchanger 11.	0.659
ASB5	ABTB1	A0A2U3WDB7	A0A2U3VLD7	LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 5.	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	0.621
ASB5	LOC101378315	A0A2U3WDB7	A0A2U3VFX0	LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 5.	Bcl10-interacting CARD protein isoform X1.	0.621
ECI2	ABTB1	A0A2U3WXS2	A0A2U3VLD7	enoyl-CoA delta isomerase 2, mitochondrial.	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	0.538
ECI2	LOC101378315	A0A2U3WXS2	A0A2U3VFX0	enoyl-CoA delta isomerase 2, mitochondrial.	Bcl10-interacting CARD protein isoform X1.	0.613
ECI2	MEGF8	A0A2U3WXS2	A0A2U3WHI3	enoyl-CoA delta isomerase 2, mitochondrial.	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8.	0.451
ECI2	PCYOX1	A0A2U3WXS2	A0A2U3VTM5	enoyl-CoA delta isomerase 2, mitochondrial.	Prenylcysteine oxidase 1 isoform X1.	0.441
ECI2	SLC22A12	A0A2U3WXS2	A0A2U3VGZ8	enoyl-CoA delta isomerase 2, mitochondrial.	Solute carrier family 22 member 12.	0.527
ECI2	SLC9C2	A0A2U3WXS2	A0A2U3ZPN9	enoyl-CoA delta isomerase 2, mitochondrial.	Sodium/hydrogen exchanger 11.	0.524
GALP	ABTB1	A0A2U3W9X8	A0A2U3VLD7	Galanin-like peptide.	Ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X1.	0.523
GALP	LOC101378315	A0A2U3W9X8	A0A2U3VFX0	Galanin-like peptide.	Bcl10-interacting CARD protein isoform X1.	0.523
GALP	MEGF8	A0A2U3W9X8	A0A2U3WHI3	Galanin-like peptide.	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8.	0.437

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Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.767

expected number of edges:

4

PPI enrichment p-value:

0.124

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070330

Aromatase activity

3 of 11

2.61

1.99

0.00021

GO:0020037

Heme binding

4 of 113

1.73

1.42

0.00099

GO:0005506

Iron ion binding

3 of 127

1.55

0.73

0.0319

GO:0003824

Catalytic activity

10 of 5203

0.46

0.31

0.0319

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30660177

(2019) Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq.

4 of 25

2.38

2.49

1.79e-05

PMID:33782952

(2021) Antimicrobial prescribing guidelines for poultry.

2 of 2

3.18

1.14

0.0088

PMID:34214746

(2021) Protective effect of glutathione S-transferase enzyme activity against aflatoxin B1 in poultry species: relationship between glutathione S-transferase enzyme kinetic parameters, and resistance to aflatoxin B1.

2 of 5

2.78

0.93

0.0204

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9381

Mixed, incl. Sulfation, and Epoxygenase P450 pathway

4 of 23

2.42

2.71

6.67e-06

CL:9383

Sulfation, and Epoxygenase P450 pathway

3 of 8

2.75

2.28

6.55e-05

CL:8025

Cytochrome P450, E-class, CYP3A, and Cytochrome P450, E-class, group I, CYP1

2 of 5

2.78

1.1

0.0103

CL:8590

Protoporphyrinogen IX biosynthetic process, and Heme transport

2 of 12

2.4

0.81

0.0333

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

apla00591

Linoleic acid metabolism

2 of 13

2.37

1.17

0.0069

apla00980

Metabolism of xenobiotics by cytochrome P450

2 of 22

2.14

1.09

0.0090

apla00830

Retinol metabolism

2 of 23

2.12

1.09

0.0090

apla00140

Steroid hormone biosynthesis

2 of 27

2.05

1.08

0.0090

apla01100

Metabolic pathways

5 of 996

0.88

0.61

0.0090

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-211859

Biological oxidations

8 of 192

1.8

3.67

1.02e-10

MAP-9749641

Aspirin ADME

4 of 21

2.46

3.12

1.09e-06

MAP-5423646

Aflatoxin activation and detoxification

3 of 14

2.51

2.19

8.12e-05

MAP-9757110

Prednisone ADME

3 of 20

2.36

2.11

0.00010

MAP-156580

Phase II - Conjugation of compounds

4 of 77

1.89

1.95

8.12e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0503

Monooxygenase

3 of 43

2.02

1.53

0.0010

KW-0349

Heme

3 of 60

1.88

1.43

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00067

Cytochrome P450

3 of 45

2.0

1.12

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008072

Cytochrome P450, E-class, CYP3A

2 of 2

3.18

1.07

0.0118

IPR002402

Cytochrome P450, E-class, group II

2 of 2

3.18

1.07

0.0118

IPR017972

Cytochrome P450, conserved site

3 of 36

2.1

1.02

0.0118

IPR036396

Cytochrome P450 superfamily

3 of 46

1.99

1.01

0.0118

IPR001128

Cytochrome P450

3 of 45

2.0

1.01

0.0118

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