STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)    
Predicted Functional Partners:
MET
Hepatocyte growth factor receptor.
    
 0.999
ERBB3
Receptor tyrosine-protein kinase erbB-3.
    
 0.921
SPINT1
Kunitz-type protease inhibitor 1.
    
 0.881
SPINT2
Kunitz-type protease inhibitor 2.
    
 0.875
EGFR
Receptor protein-tyrosine kinase.
    
 0.867
HGFAC
Hepatocyte growth factor activator.
   
0.864
HPN
Serine protease hepsin isoform X1; Belongs to the peptidase S1 family.
   
0.856
OSM
oncostatin-M.
     
 0.854
MST1R
Macrophage-stimulating protein receptor isoform X1.
    
 0.837
PTPRJ
Receptor-type tyrosine-protein phosphatase eta.
    
  0.828
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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