EIF1AD protein (Odobenus rosmarus) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EIF1AD

Probable RNA-binding protein EIF1AD. (166 aa)

Predicted Functional Partners:

FAU

0.894

LOC105757892

0.894

LOC105758044

0.894

RIOK1

0.892

LRRC47

0.794

RPS15

0.729

NOB1

0.701

DNAJB12

0.622

RIOK3

0.621

ANKMY1

0.620

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKMY1	EIF1AD	A0A2U3WTZ0	A0A2U3VGS5	Ankyrin repeat and MYND domain-containing protein 1.	Probable RNA-binding protein EIF1AD.	0.620
DNAJB12	EIF1AD	A0A2U3ZTQ2	A0A2U3VGS5	dnaJ homolog subfamily B member 12 isoform X1.	Probable RNA-binding protein EIF1AD.	0.622
EIF1AD	ANKMY1	A0A2U3VGS5	A0A2U3WTZ0	Probable RNA-binding protein EIF1AD.	Ankyrin repeat and MYND domain-containing protein 1.	0.620
EIF1AD	DNAJB12	A0A2U3VGS5	A0A2U3ZTQ2	Probable RNA-binding protein EIF1AD.	dnaJ homolog subfamily B member 12 isoform X1.	0.622
EIF1AD	FAU	A0A2U3VGS5	A0A2U3VHA3	Probable RNA-binding protein EIF1AD.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.894
EIF1AD	LOC105757892	A0A2U3VGS5	A0A2U3ZP95	Probable RNA-binding protein EIF1AD.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.894
EIF1AD	LOC105758044	A0A2U3VGS5	A0A2U3ZRP0	Probable RNA-binding protein EIF1AD.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.894
EIF1AD	LRRC47	A0A2U3VGS5	A0A2U3WFH2	Probable RNA-binding protein EIF1AD.	Leucine-rich repeat-containing protein 47.	0.794
EIF1AD	NOB1	A0A2U3VGS5	A0A2U3VFA2	Probable RNA-binding protein EIF1AD.	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	0.701
EIF1AD	RIOK1	A0A2U3VGS5	A0A2U3WBB9	Probable RNA-binding protein EIF1AD.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.892
EIF1AD	RIOK3	A0A2U3VGS5	A0A2U3WW99	Probable RNA-binding protein EIF1AD.	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.	0.621
EIF1AD	RPS15	A0A2U3VGS5	A0A2U3VKL6	Probable RNA-binding protein EIF1AD.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.729
FAU	EIF1AD	A0A2U3VHA3	A0A2U3VGS5	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Probable RNA-binding protein EIF1AD.	0.894
FAU	LOC105757892	A0A2U3VHA3	A0A2U3ZP95	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.991
FAU	LOC105758044	A0A2U3VHA3	A0A2U3ZRP0	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.991
FAU	LRRC47	A0A2U3VHA3	A0A2U3WFH2	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Leucine-rich repeat-containing protein 47.	0.592
FAU	NOB1	A0A2U3VHA3	A0A2U3VFA2	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.	0.969
FAU	RIOK1	A0A2U3VHA3	A0A2U3WBB9	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.	0.930
FAU	RIOK3	A0A2U3VHA3	A0A2U3WW99	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.	0.762
FAU	RPS15	A0A2U3VHA3	A0A2U3VKL6	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999

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Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.449

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072583

Clathrin-dependent endocytosis

7 of 28

2.58

6.31

2.86e-13

GO:0006898

Receptor-mediated endocytosis

8 of 99

2.09

5.0

1.65e-12

GO:0048268

Clathrin coat assembly

3 of 14

2.51

1.93

0.00026

GO:0150007

Clathrin-dependent synaptic vesicle endocytosis

2 of 3

3.0

1.23

0.0060

GO:2000253

Positive regulation of feeding behavior

2 of 5

2.78

1.16

0.0080

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035615

Clathrin adaptor activity

3 of 13

2.54

2.05

0.00016

GO:0060090

Molecular adaptor activity

6 of 308

1.47

1.62

4.92e-05

GO:0017124

SH3 domain binding

3 of 87

1.72

0.94

0.0131

GO:0008289

Lipid binding

5 of 619

1.09

0.7

0.0131

GO:0019904

Protein domain specific binding

4 of 407

1.17

0.6

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

8 of 59

2.31

6.39

9.77e-15

GO:0030122

AP-2 adaptor complex

4 of 4

3.18

4.56

4.80e-09

GO:0030136

Clathrin-coated vesicle

5 of 95

1.9

2.82

4.23e-07

GO:0031410

Cytoplasmic vesicle

6 of 1351

0.83

0.6

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14816

Clathrin-dependent endocytosis, and EH domain

11 of 37

2.65

11.76

1.25e-25

CL:14819

Clathrin-dependent endocytosis, and Clathrin coat

9 of 31

2.64

9.58

2.07e-20

CL:14821

Mixed, incl. EH domain, and Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain

8 of 16

2.88

9.58

2.81e-19

CL:14822

Mixed, incl. EH domain, and T-complex protein 10, C-terminal domain superfamily

6 of 11

2.92

7.01

5.99e-14

CL:14825

T-complex protein 10, C-terminal domain superfamily, and EH domain

3 of 5

2.96

2.99

3.42e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856828

Clathrin-mediated endocytosis

8 of 161

1.88

4.04

2.59e-11

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

5 of 108

1.84

2.48

2.48e-06

MAP-199991

Membrane Trafficking

8 of 701

1.24

1.55

1.29e-06

MAP-5653656

Vesicle-mediated transport

8 of 783

1.19

1.44

2.05e-06

MAP-5140745

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

2 of 8

2.58

1.22

0.0060

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005905

Clathrin-coated pit

5 of 29

2.42

3.93

1.86e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0254

Endocytosis

2 of 4

2.88

1.5

0.0019

KW-0168

Coated pit

2 of 6

2.7

1.49

0.0019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000261

EH domain

3 of 10

2.66

1.87

0.00037

IPR011992

EF-hand domain pair

4 of 207

1.47

0.77

0.0236

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00027

Eps15 homology domain

2 of 8

2.58

1.04

0.0130

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