STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (219 aa)    
Predicted Functional Partners:
CASP8
Caspase-8 isoform X1; Belongs to the peptidase C14A family.
   
 0.999
RIPK1
Receptor-interacting serine/threonine-protein kinase 1.
   
 0.999
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1.
   
 0.999
FAS
Tumor necrosis factor receptor superfamily member 6.
   
 0.998
CASP10
Caspase-10 isoform X1; Belongs to the peptidase C14A family.
   
 0.996
RIPK3
Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.993
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.992
CFLAR
CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family.
    
 0.989
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A.
   
 0.987
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.962
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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