node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFMID | DDC | A0A2U3ZWX5 | A0A2U3WZH7 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | aromatic-L-amino-acid decarboxylase. | 0.927 |
AFMID | IDO1 | A0A2U3ZWX5 | A0A2U3VI51 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Indoleamine 2,3-dioxygenase 1. | 0.951 |
AFMID | IDO2 | A0A2U3ZWX5 | A0A2U3VI31 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Indoleamine 2,3-dioxygenase 2. | 0.975 |
AFMID | KYNU | A0A2U3ZWX5 | A0A2U3WBM3 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.977 |
AFMID | TDO2 | A0A2U3ZWX5 | A0A2U3VHK8 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.976 |
ASMTL | DDC | A0A2U3VX03 | A0A2U3WZH7 | N-acetylserotonin O-methyltransferase-like protein. | aromatic-L-amino-acid decarboxylase. | 0.408 |
ASMTL | TDO2 | A0A2U3VX03 | A0A2U3VHK8 | N-acetylserotonin O-methyltransferase-like protein. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.951 |
DDC | AFMID | A0A2U3WZH7 | A0A2U3ZWX5 | aromatic-L-amino-acid decarboxylase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.927 |
DDC | ASMTL | A0A2U3WZH7 | A0A2U3VX03 | aromatic-L-amino-acid decarboxylase. | N-acetylserotonin O-methyltransferase-like protein. | 0.408 |
DDC | IDO1 | A0A2U3WZH7 | A0A2U3VI51 | aromatic-L-amino-acid decarboxylase. | Indoleamine 2,3-dioxygenase 1. | 0.908 |
DDC | IDO2 | A0A2U3WZH7 | A0A2U3VI31 | aromatic-L-amino-acid decarboxylase. | Indoleamine 2,3-dioxygenase 2. | 0.909 |
DDC | IL4I1 | A0A2U3WZH7 | A0A2U3WLX3 | aromatic-L-amino-acid decarboxylase. | L-amino-acid oxidase. | 0.905 |
DDC | LOC101374427 | A0A2U3WZH7 | A0A2U3WDU6 | aromatic-L-amino-acid decarboxylase. | Amine oxidase. | 0.905 |
DDC | TDO2 | A0A2U3WZH7 | A0A2U3VHK8 | aromatic-L-amino-acid decarboxylase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.908 |
DDC | TPH1 | A0A2U3WZH7 | A0A2U3WT29 | aromatic-L-amino-acid decarboxylase. | Tryptophan 5-hydroxylase 1. | 0.961 |
DDC | TPH2 | A0A2U3WZH7 | A0A2U3WC72 | aromatic-L-amino-acid decarboxylase. | Tryptophan 5-hydroxylase 2 isoform X1. | 0.942 |
IDO1 | AFMID | A0A2U3VI51 | A0A2U3ZWX5 | Indoleamine 2,3-dioxygenase 1. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.951 |
IDO1 | DDC | A0A2U3VI51 | A0A2U3WZH7 | Indoleamine 2,3-dioxygenase 1. | aromatic-L-amino-acid decarboxylase. | 0.908 |
IDO1 | IDO2 | A0A2U3VI51 | A0A2U3VI31 | Indoleamine 2,3-dioxygenase 1. | Indoleamine 2,3-dioxygenase 2. | 0.904 |
IDO1 | IL4I1 | A0A2U3VI51 | A0A2U3WLX3 | Indoleamine 2,3-dioxygenase 1. | L-amino-acid oxidase. | 0.909 |