UBR7 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

UBR7

Putative E3 ubiquitin-protein ligase UBR7. (425 aa)

Predicted Functional Partners:

NASP

0.788

UNC79

0.718

WDR76

0.716

DYM

0.704

BTBD7

0.663

DSCC1

0.658

TMEM194A

0.658

GINS2

0.637

CASP8AP2

0.634

ATAD2

0.634

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD2	CASP8AP2	A0A2U3WMX7	A0A2U3W7Z8	ATPase family AAA domain-containing protein 2.	CASP8-associated protein 2.	0.645
ATAD2	DSCC1	A0A2U3WMX7	A0A2U3WSM0	ATPase family AAA domain-containing protein 2.	Sister chromatid cohesion protein DCC1.	0.576
ATAD2	GINS2	A0A2U3WMX7	A0A2U3VCP2	ATPase family AAA domain-containing protein 2.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.491
ATAD2	NASP	A0A2U3WMX7	A0A2U3VYP6	ATPase family AAA domain-containing protein 2.	Nuclear autoantigenic sperm protein isoform X1.	0.564
ATAD2	UBR7	A0A2U3WMX7	A0A2U3VI83	ATPase family AAA domain-containing protein 2.	Putative E3 ubiquitin-protein ligase UBR7.	0.634
ATAD2	WDR76	A0A2U3WMX7	A0A2U3WQH3	ATPase family AAA domain-containing protein 2.	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.	0.774
BTBD7	DYM	A0A2U3VIK9	A0A2U3WII9	BTB/POZ domain-containing protein 7 isoform X1.	Dymeclin isoform X1.	0.721
BTBD7	UBR7	A0A2U3VIK9	A0A2U3VI83	BTB/POZ domain-containing protein 7 isoform X1.	Putative E3 ubiquitin-protein ligase UBR7.	0.663
BTBD7	UNC79	A0A2U3VIK9	A0A2U3VI90	BTB/POZ domain-containing protein 7 isoform X1.	Protein unc-79 homolog isoform X1.	0.720
CASP8AP2	ATAD2	A0A2U3W7Z8	A0A2U3WMX7	CASP8-associated protein 2.	ATPase family AAA domain-containing protein 2.	0.645
CASP8AP2	DSCC1	A0A2U3W7Z8	A0A2U3WSM0	CASP8-associated protein 2.	Sister chromatid cohesion protein DCC1.	0.623
CASP8AP2	GINS2	A0A2U3W7Z8	A0A2U3VCP2	CASP8-associated protein 2.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.621
CASP8AP2	NASP	A0A2U3W7Z8	A0A2U3VYP6	CASP8-associated protein 2.	Nuclear autoantigenic sperm protein isoform X1.	0.529
CASP8AP2	UBR7	A0A2U3W7Z8	A0A2U3VI83	CASP8-associated protein 2.	Putative E3 ubiquitin-protein ligase UBR7.	0.634
CASP8AP2	WDR76	A0A2U3W7Z8	A0A2U3WQH3	CASP8-associated protein 2.	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.	0.703
DSCC1	ATAD2	A0A2U3WSM0	A0A2U3WMX7	Sister chromatid cohesion protein DCC1.	ATPase family AAA domain-containing protein 2.	0.576
DSCC1	CASP8AP2	A0A2U3WSM0	A0A2U3W7Z8	Sister chromatid cohesion protein DCC1.	CASP8-associated protein 2.	0.623
DSCC1	GINS2	A0A2U3WSM0	A0A2U3VCP2	Sister chromatid cohesion protein DCC1.	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.796
DSCC1	NASP	A0A2U3WSM0	A0A2U3VYP6	Sister chromatid cohesion protein DCC1.	Nuclear autoantigenic sperm protein isoform X1.	0.594
DSCC1	UBR7	A0A2U3WSM0	A0A2U3VI83	Sister chromatid cohesion protein DCC1.	Putative E3 ubiquitin-protein ligase UBR7.	0.658

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Network Stats

number of nodes:

9

number of edges:

15

average node degree:

3.33

avg. local clustering coefficient:

0.917

expected number of edges:

16

PPI enrichment p-value:

0.675

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006479

Protein methylation

6 of 57

1.9

2.91

2.29e-07

GO:0016571

Histone methylation

4 of 25

2.08

2.31

2.22e-05

GO:0006325

Chromatin organization

7 of 177

1.48

2.04

8.15e-07

GO:0051568

Histone H3-K4 methylation

3 of 11

2.31

1.91

0.00024

GO:0016570

Histone modification

5 of 88

1.63

1.88

2.97e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

3 of 9

2.4

1.75

0.00055

GO:0046982

Protein heterodimerization activity

3 of 29

1.89

1.13

0.0061

GO:0042800

Histone methyltransferase activity (H3-K4 specific)

2 of 5

2.48

0.98

0.0162

GO:0005515

Protein binding

6 of 689

0.82

0.48

0.0311

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

4 of 9

2.53

3.22

7.64e-07

GO:0048188

Set1C/COMPASS complex

3 of 8

2.45

2.34

3.90e-05

GO:0000786

Nucleosome

3 of 11

2.31

2.18

6.80e-05

GO:0005694

Chromosome

8 of 326

1.27

1.64

7.64e-07

GO:0070210

Rpd3L-Expanded complex

2 of 3

2.7

1.62

0.0011

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34202282

(2021) Using Genealogical Concordance and Coalescent-Based Species Delimitation to Assess Species Boundaries in the Diaporthe eres Complex.

2 of 2

2.88

1.82

0.00049

PMID:25264384

(2014) Species limits in Diaporthe: molecular re-assessment of D. citri, D. cytosporella, D. foeniculina and D. rudis.

2 of 2

2.88

1.82

0.00049

PMID:34456375

(2020) Mating genes in Calonectria and evidence for a heterothallic ancestral state.

2 of 3

2.7

1.81

0.00049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2696

Histone methyltransferase complex, and Structural constituent of chromatin

8 of 25

2.38

6.92

1.24e-15

CL:2689

PKMTs methylate histone lysines, and Structural constituent of chromatin

9 of 37

2.26

6.86

1.78e-16

CL:2475

Mixed, incl. Histone modification, and Chromatin remodeling

10 of 171

1.65

3.75

3.88e-14

CL:2726

Set1C/COMPASS complex, and Histone H3

4 of 10

2.48

3.49

1.97e-07

CL:2699

Mixed, incl. Nucleosome core, and Regulation of PTEN gene transcription

4 of 13

2.37

3.26

4.33e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00310

Lysine degradation

3 of 82

1.44

0.76

0.0240

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 29

2.11

3.1

3.48e-07

MAP-4839726

Chromatin organization

6 of 81

1.75

2.62

3.48e-07

MAP-3247509

Chromatin modifying enzymes

6 of 81

1.75

2.62

3.48e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.28

1.66

0.00072

GOCC:0035097

Histone methyltransferase complex

3 of 14

2.21

1.65

0.00072

GOCC:0070210

Rpd3L-Expanded complex

2 of 5

2.48

1.31

0.0039

GOCC:0000785

Chromatin

5 of 145

1.42

1.26

0.00072

GOCC:0048188

Set1C/COMPASS complex

2 of 7

2.33

1.2

0.0060

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 10

2.36

2.07

0.00012

KW-0544

Nucleosome core

2 of 5

2.48

1.4

0.0026

KW-0539

Nucleus

6 of 309

1.17

1.16

0.00013

KW-0853

WD repeat

3 of 99

1.36

0.79

0.0164

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007125

Histone H2A/H2B/H3

3 of 6

2.58

1.85

0.00038

IPR000164

Histone H3/CENP-A

2 of 2

2.88

1.15

0.0083

IPR009072

Histone-fold

3 of 25

1.96

1.11

0.0073

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

2 of 3

2.7

1.27

0.0049

SM00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

2 of 14

2.03

0.82

0.0292

SM00320

WD40 repeats

3 of 113

1.3

0.63

0.0415

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