node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREBBP | MED1 | A0A2U3W573 | A0A2U3VJP3 | CREB-binding protein isoform X1. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.717 |
CREBBP | NCOA1 | A0A2U3W573 | A0A2U3VJC3 | CREB-binding protein isoform X1. | Nuclear receptor coactivator. | 0.993 |
CREBBP | NCOR1 | A0A2U3W573 | A0A2U3WZQ5 | CREB-binding protein isoform X1. | Nuclear receptor corepressor 1 isoform X1. | 0.767 |
CREBBP | NCOR2 | A0A2U3W573 | A0A2U3VLV1 | CREB-binding protein isoform X1. | Nuclear receptor corepressor 2. | 0.659 |
CREBBP | PPARG | A0A2U3W573 | A0A2U3VLH3 | CREB-binding protein isoform X1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.965 |
CREBBP | PPARGC1A | A0A2U3W573 | A0A2U3W491 | CREB-binding protein isoform X1. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. | 0.627 |
CREBBP | RXRA | A0A2U3W573 | A0A2U3ZRS6 | CREB-binding protein isoform X1. | Retinoic acid receptor RXR-alpha isoform X1. | 0.921 |
CREBBP | RXRG | A0A2U3W573 | A0A2U3WI17 | CREB-binding protein isoform X1. | Retinoic acid receptor RXR-gamma isoform X1. | 0.875 |
CREBBP | SIRT1 | A0A2U3W573 | A0A2U3VGM8 | CREB-binding protein isoform X1. | NAD-dependent protein deacetylase sirtuin-1 isoform X1. | 0.592 |
MED1 | CREBBP | A0A2U3VJP3 | A0A2U3W573 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | CREB-binding protein isoform X1. | 0.717 |
MED1 | NCOA1 | A0A2U3VJP3 | A0A2U3VJC3 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.666 |
MED1 | NCOR1 | A0A2U3VJP3 | A0A2U3WZQ5 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 1 isoform X1. | 0.551 |
MED1 | NCOR2 | A0A2U3VJP3 | A0A2U3VLV1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 2. | 0.585 |
MED1 | PPARG | A0A2U3VJP3 | A0A2U3VLH3 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.964 |
MED1 | RXRA | A0A2U3VJP3 | A0A2U3ZRS6 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-alpha isoform X1. | 0.926 |
MED1 | RXRG | A0A2U3VJP3 | A0A2U3WI17 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-gamma isoform X1. | 0.926 |
MTOR | PPARG | A0A2U3WPU6 | A0A2U3VLH3 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.944 |
MTOR | SIRT1 | A0A2U3WPU6 | A0A2U3VGM8 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | NAD-dependent protein deacetylase sirtuin-1 isoform X1. | 0.562 |
NCOA1 | CREBBP | A0A2U3VJC3 | A0A2U3W573 | Nuclear receptor coactivator. | CREB-binding protein isoform X1. | 0.993 |
NCOA1 | MED1 | A0A2U3VJC3 | A0A2U3VJP3 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.666 |