STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSENENGamma-secretase subunit PEN-2. (101 aa)    
Predicted Functional Partners:
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.999
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.999
NCSTN
Nicastrin isoform X1.
    
 0.999
APH1A
Gamma-secretase subunit APH-1A isoform X1.
   
 0.996
APH1B
Gamma-secretase subunit APH-1B isoform X1.
   
 0.996
NOTCH1
Neurogenic locus notch homolog protein 1.
    
 0.906
APP
Amyloid beta A4 protein isoform X1.
    
 0.849
NOTCH3
Neurogenic locus notch homolog protein 3.
    
 0.738
NOTCH2
Neurogenic locus notch homolog protein 2.
    
 0.737
BACE1
Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family.
      
 0.722
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.