STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1116 aa)    
Predicted Functional Partners:
RNF41
E3 ubiquitin-protein ligase NRDP1.
    
 0.972
STAM2
Signal transducing adapter molecule 2 isoform X1.
    
 0.965
EGFR
Receptor protein-tyrosine kinase.
    
 0.964
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
   
 0.946
PARK2
RBR-type E3 ubiquitin transferase.
     
 0.934
RPS27A
ubiquitin-40S ribosomal protein S27a.
    
 0.913
UBA52
ubiquitin-60S ribosomal protein L40 isoform X1.
   
 0.880
YWHAZ
14-3-3 protein zeta/delta isoform X1; Belongs to the 14-3-3 family.
    
 0.862
STAM
Signal transducing adapter molecule 1 isoform X1.
    
 0.795
UBC
polyubiquitin-C.
   
 0.760
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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