ATR protein (Odobenus rosmarus) - STRING interaction network

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ATR

Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)

Predicted Functional Partners:

ATM

0.998

CHEK1

0.998

ATRIP

0.998

CHEK2

0.993

FANCM

0.991

WRN

0.988

TELO2

0.984

RAD1

0.983

CDC7

0.977

TP53

0.976

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	A0A2U3VZR5	A0A2U3VQ83	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.998
ATM	ATRIP	A0A2U3VZR5	A0A2U3ZEJ1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR-interacting protein isoform X1.	0.875
ATM	CHEK1	A0A2U3VZR5	A0A2U3X517	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	0.974
ATM	CHEK2	A0A2U3VZR5	A0A2U3VXA1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk2 isoform X1.	0.995
ATM	FANCM	A0A2U3VZR5	A0A2U3ZWL6	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Fanconi anemia group M protein.	0.668
ATM	RAD1	A0A2U3VZR5	A0A2U3WU65	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle checkpoint protein RAD1.	0.866
ATM	TELO2	A0A2U3VZR5	A0A2U3W530	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere length regulation protein TEL2 homolog.	0.889
ATM	TP53	A0A2U3VZR5	A0A2U3VT95	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
ATM	WRN	A0A2U3VZR5	A0A2U3WHU5	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Werner syndrome ATP-dependent helicase.	0.960
ATR	ATM	A0A2U3VQ83	A0A2U3VZR5	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
ATR	ATRIP	A0A2U3VQ83	A0A2U3ZEJ1	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	ATR-interacting protein isoform X1.	0.998
ATR	CDC7	A0A2U3VQ83	A0A2U3W3I5	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell division cycle 7-related protein kinase isoform X1.	0.977
ATR	CHEK1	A0A2U3VQ83	A0A2U3X517	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	0.998
ATR	CHEK2	A0A2U3VQ83	A0A2U3VXA1	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase Chk2 isoform X1.	0.993
ATR	FANCM	A0A2U3VQ83	A0A2U3ZWL6	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Fanconi anemia group M protein.	0.991
ATR	RAD1	A0A2U3VQ83	A0A2U3WU65	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint protein RAD1.	0.983
ATR	TELO2	A0A2U3VQ83	A0A2U3W530	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Telomere length regulation protein TEL2 homolog.	0.984
ATR	TP53	A0A2U3VQ83	A0A2U3VT95	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.976
ATR	WRN	A0A2U3VQ83	A0A2U3WHU5	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Werner syndrome ATP-dependent helicase.	0.988
ATRIP	ATM	A0A2U3ZEJ1	A0A2U3VZR5	ATR-interacting protein isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.875