STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)    
Predicted Functional Partners:
DDIT3
DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]
   
 0.990
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1.
     
 0.965
EP300
Histone acetyltransferase p300.
    
 0.960
CREBBP
CREB-binding protein isoform X1.
    
 0.959
CEBPB
CCAAT/enhancer-binding protein.
   
 0.957
EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.
     
 0.947
CREB1
Cyclic AMP-responsive element-binding protein 1 isoform X1.
    
 0.944
ATF2
Cyclic AMP-dependent transcription factor ATF-2 isoform X1.
    
 0.938
ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta isoform X2.
     
 0.932
CREB5
Cyclic AMP-responsive element-binding protein 5.
    
 0.930
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.