node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPI | CD14 | A0A2U3VEV0 | A0A2U3VRG5 | Bactericidal permeability-increasing protein. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.645 |
BPI | LBP | A0A2U3VEV0 | A0A2U3VEY6 | Bactericidal permeability-increasing protein. | Lipopolysaccharide-binding protein isoform X1. | 0.557 |
BPI | LOC101370586 | A0A2U3VEV0 | A0A2U3ZX02 | Bactericidal permeability-increasing protein. | Lipopolysaccharide-binding protein-like. | 0.558 |
BPI | LY96 | A0A2U3VEV0 | A0A2U3W6Y1 | Bactericidal permeability-increasing protein. | Lymphocyte antigen 96. | 0.543 |
BPI | TLR4 | A0A2U3VEV0 | A0A2U3X221 | Bactericidal permeability-increasing protein. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.549 |
CD14 | BPI | A0A2U3VRG5 | A0A2U3VEV0 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Bactericidal permeability-increasing protein. | 0.645 |
CD14 | LBP | A0A2U3VRG5 | A0A2U3VEY6 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lipopolysaccharide-binding protein isoform X1. | 0.645 |
CD14 | LOC101367407 | A0A2U3VRG5 | A0A2U3Z9K3 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Uncharacterized protein LOC101367407. | 0.948 |
CD14 | LOC101370586 | A0A2U3VRG5 | A0A2U3ZX02 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lipopolysaccharide-binding protein-like. | 0.645 |
CD14 | LY96 | A0A2U3VRG5 | A0A2U3W6Y1 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Lymphocyte antigen 96. | 0.983 |
CD14 | PLCG2 | A0A2U3VRG5 | A0A2U3VC63 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.759 |
CD14 | SPI1 | A0A2U3VRG5 | A0A2U3ZEX5 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Transcription factor PU.1 isoform X1. | 0.906 |
CD14 | TLR2 | A0A2U3VRG5 | A0A2U3VHM7 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor 2; Belongs to the Toll-like receptor family. | 0.948 |
CD14 | TLR4 | A0A2U3VRG5 | A0A2U3X221 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.984 |
CD14 | TYROBP | A0A2U3VRG5 | A0A2U3VN63 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TYRO protein tyrosine kinase-binding protein isoform X1. | 0.622 |
LBP | BPI | A0A2U3VEY6 | A0A2U3VEV0 | Lipopolysaccharide-binding protein isoform X1. | Bactericidal permeability-increasing protein. | 0.557 |
LBP | CD14 | A0A2U3VEY6 | A0A2U3VRG5 | Lipopolysaccharide-binding protein isoform X1. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.645 |
LBP | LOC101370586 | A0A2U3VEY6 | A0A2U3ZX02 | Lipopolysaccharide-binding protein isoform X1. | Lipopolysaccharide-binding protein-like. | 0.903 |
LBP | LY96 | A0A2U3VEY6 | A0A2U3W6Y1 | Lipopolysaccharide-binding protein isoform X1. | Lymphocyte antigen 96. | 0.543 |
LBP | TLR4 | A0A2U3VEY6 | A0A2U3X221 | Lipopolysaccharide-binding protein isoform X1. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.549 |