KRBA2 protein (Odobenus rosmarus) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

KRBA2

KRAB-A domain-containing protein 2. (427 aa)

Predicted Functional Partners:

FANCM

0.765

MAP3K19

0.704

ADGRL3

0.575

KHDRBS2

0.558

LOC101380461

0.530

LOC101373232

0.523

LOC101380170

0.521

CTNNA3

0.521

CCSER1

0.497

THSD7B

0.497

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRL3	KRBA2	A0A2U3VJF2	A0A2U3VTA9	Latrophilin-3 isoform X1; Belongs to the G-protein coupled receptor 2 family.	KRAB-A domain-containing protein 2.	0.575
ADGRL3	THSD7B	A0A2U3VJF2	A0A2U3WQG6	Latrophilin-3 isoform X1; Belongs to the G-protein coupled receptor 2 family.	Thrombospondin type-1 domain-containing protein 7B.	0.539
CCSER1	KRBA2	A0A2U3VAT7	A0A2U3VTA9	Serine-rich coiled-coil domain-containing protein 1.	KRAB-A domain-containing protein 2.	0.497
CTNNA3	KRBA2	A0A2U3ZVF1	A0A2U3VTA9	LOW QUALITY PROTEIN: catenin alpha-3.	KRAB-A domain-containing protein 2.	0.521
CTNNA3	MAP3K19	A0A2U3ZVF1	A0A2U3W612	LOW QUALITY PROTEIN: catenin alpha-3.	Mitogen-activated protein kinase kinase kinase 19 isoform X1.	0.439
FANCM	KRBA2	A0A2U3ZWL6	A0A2U3VTA9	Fanconi anemia group M protein.	KRAB-A domain-containing protein 2.	0.765
KHDRBS2	KRBA2	A0A2U3W367	A0A2U3VTA9	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	KRAB-A domain-containing protein 2.	0.558
KHDRBS2	LOC101380170	A0A2U3W367	A0A2U3WYZ8	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	Uncharacterized protein C12orf29 homolog.	0.521
KHDRBS2	LOC101380461	A0A2U3W367	A0A2U3WZ08	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	Uncharacterized protein C12orf50 homolog isoform X1.	0.525
KHDRBS2	MAP3K19	A0A2U3W367	A0A2U3W612	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	Mitogen-activated protein kinase kinase kinase 19 isoform X1.	0.521
KHDRBS2	THSD7B	A0A2U3W367	A0A2U3WQG6	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	Thrombospondin type-1 domain-containing protein 7B.	0.521
KRBA2	ADGRL3	A0A2U3VTA9	A0A2U3VJF2	KRAB-A domain-containing protein 2.	Latrophilin-3 isoform X1; Belongs to the G-protein coupled receptor 2 family.	0.575
KRBA2	CCSER1	A0A2U3VTA9	A0A2U3VAT7	KRAB-A domain-containing protein 2.	Serine-rich coiled-coil domain-containing protein 1.	0.497
KRBA2	CTNNA3	A0A2U3VTA9	A0A2U3ZVF1	KRAB-A domain-containing protein 2.	LOW QUALITY PROTEIN: catenin alpha-3.	0.521
KRBA2	FANCM	A0A2U3VTA9	A0A2U3ZWL6	KRAB-A domain-containing protein 2.	Fanconi anemia group M protein.	0.765
KRBA2	KHDRBS2	A0A2U3VTA9	A0A2U3W367	KRAB-A domain-containing protein 2.	KH domain-containing, RNA-binding, signal transduction-associated protein 2.	0.558
KRBA2	LOC101373232	A0A2U3VTA9	A0A2U3VRQ9	KRAB-A domain-containing protein 2.	Protocadherin alpha-C2 isoform X1.	0.523
KRBA2	LOC101380170	A0A2U3VTA9	A0A2U3WYZ8	KRAB-A domain-containing protein 2.	Uncharacterized protein C12orf29 homolog.	0.521
KRBA2	LOC101380461	A0A2U3VTA9	A0A2U3WZ08	KRAB-A domain-containing protein 2.	Uncharacterized protein C12orf50 homolog isoform X1.	0.530
KRBA2	MAP3K19	A0A2U3VTA9	A0A2U3W612	KRAB-A domain-containing protein 2.	Mitogen-activated protein kinase kinase kinase 19 isoform X1.	0.704

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

5

average node degree:

2.5

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

5 of 8

2.22

3.2

3.54e-07

GO:0006096

Glycolytic process

3 of 18

1.65

0.95

0.0111

GO:0006091

Generation of precursor metabolites and energy

4 of 79

1.13

0.73

0.0118

GO:0032787

Monocarboxylic acid metabolic process

4 of 83

1.11

0.72

0.0123

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016668

Oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

5 of 7

2.28

3.47

1.12e-07

GO:0050660

Flavin adenine dinucleotide binding

5 of 21

1.8

2.4

3.03e-06

GO:0004148

Dihydrolipoyl dehydrogenase activity

3 of 3

2.43

2.11

0.00011

GO:0016746

Acyltransferase activity

5 of 70

1.28

1.19

0.00044

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

2 of 5

2.03

0.88

0.0216

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045254

Pyruvate dehydrogenase complex

2 of 3

2.25

1.27

0.0042

GO:0009274

Peptidoglycan-based cell wall

5 of 113

1.07

0.8

0.0042

GO:0005737

Cytoplasm

10 of 870

0.49

0.37

0.0042

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1070

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and e3 binding domain

8 of 11

2.29

6.17

2.64e-14

CL:1067

Mixed, incl. Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

9 of 17

2.15

6.1

2.35e-15

CL:1082

Lysine degradation, and Dehydrogenase E1 component

5 of 5

2.43

4.15

6.59e-09

CL:1072

e3 binding domain, and Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 5

2.2

1.95

0.00017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ppc00020

Citrate cycle (TCA cycle)

6 of 27

1.77

2.9

5.20e-08

ppc00380

Tryptophan metabolism

4 of 7

2.18

2.87

1.64e-06

ppc00310

Lysine degradation

4 of 7

2.18

2.87

1.64e-06

ppc00280

Valine, leucine and isoleucine degradation

4 of 13

1.91

2.51

3.40e-06

ppc00620

Pyruvate metabolism

5 of 29

1.66

2.29

1.64e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

6 of 64

1.4

1.84

1.58e-06

MAP-9635486

Infection with Mycobacterium tuberculosis

6 of 114

1.15

1.25

2.04e-05

MAP-5663205

Infectious disease

6 of 115

1.14

1.24

2.04e-05

MAP-1643685

Disease

6 of 117

1.14

1.23

2.04e-05

MAP-9636383

Prevention of phagosomal-lysosomal fusion

3 of 33

1.39

1.16

0.0013

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 33

1.75

3.16

3.81e-09

GOCC:0045252

Oxoglutarate dehydrogenase complex

2 of 2

2.43

1.36

0.0031

GOCC:0045254

Pyruvate dehydrogenase complex

2 of 4

2.13

1.21

0.0051

GOCC:0032991

Protein-containing complex

8 of 361

0.77

0.65

0.00054

GOCC:0005737

Cytoplasm

10 of 767

0.54

0.44

0.00080

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

5 of 11

2.08

3.16

2.02e-07

KW-0676

Redox-active center

4 of 10

2.03

2.5

6.49e-06

KW-0450

Lipoyl

3 of 4

2.3

2.24

5.07e-05

KW-0520

NAD

5 of 46

1.46

1.69

2.56e-05

KW-0012

Acyltransferase

3 of 24

1.52

1.13

0.0029

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

5 of 5

2.43

3.87

2.60e-08

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

4 of 4

2.43

3.03

1.52e-06

PF02817

e3 binding domain

3 of 3

2.43

2.11

0.00011

PF13738

Pyridine nucleotide-disulphide oxidoreductase

3 of 5

2.2

1.9

0.00022

PF00364

Biotin-requiring enzyme

3 of 7

2.06

1.74

0.00038

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 5

2.03

0.85

0.0250

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