STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)    
Predicted Functional Partners:
PRKAR1A
cAMP-dependent protein kinase type I-alpha regulatory subunit.
 
 
 0.999
PRKAR1B
cAMP-dependent protein kinase type I-beta regulatory subunit.
 
 
 0.999
PKIA
cAMP-dependent protein kinase inhibitor alpha.
   
 0.999
PRKAR2B
cAMP-dependent protein kinase type II-beta regulatory subunit.
 
 
 0.995
PPP1R1B
Protein phosphatase 1 regulatory subunit 1B.
    
 0.994
PRKAR2A
cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1.
 
 
 0.983
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.980
CREB1
Cyclic AMP-responsive element-binding protein 1 isoform X1.
    
 0.978
PDE4B
Phosphodiesterase.
   
 0.977
GLI3
Transcriptional activator GLI3.
    
 0.976
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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