STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)    
Predicted Functional Partners:
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 
 0.999
IL1R2
Interleukin-1 receptor type 2.
   
 0.994
IL1R1
Interleukin-1 receptor type 1.
   
 0.987
IL1RAP
Interleukin-1 receptor accessory protein.
   
 0.972
LOC101382016
Caspase-13-like; Belongs to the peptidase C14A family.
   
 0.937
TNF
Tumor necrosis factor; Belongs to the tumor necrosis factor family.
   
 
 0.918
CAPN2
Calpain-2 catalytic subunit; Belongs to the peptidase C2 family.
   
 
 0.903
CAPN1
Calpain-1 catalytic subunit; Belongs to the peptidase C2 family.
   
 
 0.903
IL6
Interleukin-6 isoform X1.
   
 
 0.885
IL1RL2
Interleukin-1 receptor-like 2.
   
 0.876
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.