TSPAN1 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

TSPAN1

Tetraspanin. (244 aa)

Predicted Functional Partners:

CDHR2

0.621

TSPAN13

0.544

METTL7B

0.538

TSC22D2

0.525

RBM26

0.524

CACNG1

0.523

FAM65B

0.521

OSTF1

0.511

GKN2

0.491

TSPAN31

0.452

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNG1	TSPAN1	A0A2U3X192	A0A2U3VYP2	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.	Tetraspanin.	0.523
CACNG1	TSPAN13	A0A2U3X192	A0A2U3VXS0	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.	Tetraspanin-13; Belongs to the tetraspanin (TM4SF) family.	0.442
CDHR2	TSPAN1	A0A2U3ZHR7	A0A2U3VYP2	Cadherin-related family member 2.	Tetraspanin.	0.621
FAM65B	TSPAN1	A0A2U3WDE4	A0A2U3VYP2	Protein FAM65B isoform X1.	Tetraspanin.	0.521
GKN2	TSC22D2	A0A2U3VQS8	A0A2U3W9S3	Gastrokine-2.	TSC22 domain family protein 2 isoform X1.	0.713
GKN2	TSPAN1	A0A2U3VQS8	A0A2U3VYP2	Gastrokine-2.	Tetraspanin.	0.491
METTL7B	TSPAN1	A0A2U3W1N0	A0A2U3VYP2	LOW QUALITY PROTEIN: methyltransferase-like protein 7B.	Tetraspanin.	0.538
OSTF1	TSPAN1	A0A2U3VP48	A0A2U3VYP2	Osteoclast-stimulating factor 1.	Tetraspanin.	0.511
RBM26	TSPAN1	A0A2U3VZ35	A0A2U3VYP2	RNA-binding protein 26 isoform X1.	Tetraspanin.	0.524
TSC22D2	GKN2	A0A2U3W9S3	A0A2U3VQS8	TSC22 domain family protein 2 isoform X1.	Gastrokine-2.	0.713
TSC22D2	TSPAN1	A0A2U3W9S3	A0A2U3VYP2	TSC22 domain family protein 2 isoform X1.	Tetraspanin.	0.525
TSPAN1	CACNG1	A0A2U3VYP2	A0A2U3X192	Tetraspanin.	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.	0.523
TSPAN1	CDHR2	A0A2U3VYP2	A0A2U3ZHR7	Tetraspanin.	Cadherin-related family member 2.	0.621
TSPAN1	FAM65B	A0A2U3VYP2	A0A2U3WDE4	Tetraspanin.	Protein FAM65B isoform X1.	0.521
TSPAN1	GKN2	A0A2U3VYP2	A0A2U3VQS8	Tetraspanin.	Gastrokine-2.	0.491
TSPAN1	METTL7B	A0A2U3VYP2	A0A2U3W1N0	Tetraspanin.	LOW QUALITY PROTEIN: methyltransferase-like protein 7B.	0.538
TSPAN1	OSTF1	A0A2U3VYP2	A0A2U3VP48	Tetraspanin.	Osteoclast-stimulating factor 1.	0.511
TSPAN1	RBM26	A0A2U3VYP2	A0A2U3VZ35	Tetraspanin.	RNA-binding protein 26 isoform X1.	0.524
TSPAN1	TSC22D2	A0A2U3VYP2	A0A2U3W9S3	Tetraspanin.	TSC22 domain family protein 2 isoform X1.	0.525
TSPAN1	TSPAN13	A0A2U3VYP2	A0A2U3VXS0	Tetraspanin.	Tetraspanin-13; Belongs to the tetraspanin (TM4SF) family.	0.544

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.849

expected number of edges:

11

PPI enrichment p-value:

1.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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