STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOSBProtein fosB isoform X1. (338 aa)    
Predicted Functional Partners:
JUND
LOW QUALITY PROTEIN: transcription factor jun-D.
   
 0.999
JUN
Transcription factor AP-1 isoform X1; Belongs to the bZIP family.
   
 0.999
FOS
Proto-oncogene c-Fos isoform X1.
  
0.992
JUNB
Transcription factor jun-B.
   
 0.983
FOSL2
Fos-related antigen 2 isoform X1.
   
0.972
FOSL1
Fos-related antigen 1 isoform X1.
     
0.947
HDAC2
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.932
HDAC1
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.932
SIRT1
NAD-dependent protein deacetylase sirtuin-1 isoform X1.
    
 0.908
EGR1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.890
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.