STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (918 aa)    
Predicted Functional Partners:
SIRT1
NAD-dependent protein deacetylase sirtuin-1 isoform X1.
    
 0.877
RANBP3
Ran-binding protein 3.
   
    0.788
TMBIM6
Bax inhibitor 1; Belongs to the BI1 family.
      
 0.712
EDC4
Enhancer of mRNA-decapping protein 4.
   
    0.692
RBM39
RNA-binding protein 39 isoform X2.
   
 0.615
PSMB10
Proteasome subunit beta.
    
 
 0.603
RNF40
E3 ubiquitin protein ligase; Belongs to the BRE1 family.
   
    0.593
HAO1
Hydroxyacid oxidase 1.
    
   0.575
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]
    
 0.551
DDX46
Probable ATP-dependent RNA helicase DDX46 isoform X1.
   
 0.543
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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