AGO1 protein (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AGO1

Protein argonaute-1 isoform X1; Belongs to the argonaute family. (857 aa)

Predicted Functional Partners:

DICER1

0.860

TNRC6A

0.806

TNRC6C

0.802

DROSHA

0.772

LOC101366593

0.766

AGO2

0.766

TARBP2

0.738

PRKRA

0.692

MRPL44

0.667

STAU2

0.628

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	A0A2U3W3V7	A0A2U3ZKX6	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.766
AGO1	DICER1	A0A2U3W3V7	A0A2U3VI99	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.860
AGO1	DROSHA	A0A2U3W3V7	A0A2U3WR15	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Ribonuclease 3 isoform X1.	0.772
AGO1	LOC101366593	A0A2U3W3V7	A0A2U3ZKR2	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	LOW QUALITY PROTEIN: protein argonaute-2-like.	0.766
AGO1	MRPL44	A0A2U3W3V7	A0A2U3WFS7	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	39S ribosomal protein L44, mitochondrial isoform X2.	0.667
AGO1	PRKRA	A0A2U3W3V7	A0A2U3W6H7	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Interferon-inducible double-stranded RNA-dependent protein kinase activator A.	0.692
AGO1	STAU2	A0A2U3W3V7	A0A2U3ZJ73	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Double-stranded RNA-binding protein Staufen homolog 2 isoform X1.	0.628
AGO1	TARBP2	A0A2U3W3V7	A0A2U3WCQ3	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.738
AGO1	TNRC6A	A0A2U3W3V7	A0A2U3ZF29	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6A protein.	0.806
AGO1	TNRC6C	A0A2U3W3V7	A0A2U3VI13	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6C protein isoform X1.	0.802
AGO2	AGO1	A0A2U3ZKX6	A0A2U3W3V7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.766
AGO2	DICER1	A0A2U3ZKX6	A0A2U3VI99	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.952
AGO2	DROSHA	A0A2U3ZKX6	A0A2U3WR15	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ribonuclease 3 isoform X1.	0.823
AGO2	MRPL44	A0A2U3ZKX6	A0A2U3WFS7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	39S ribosomal protein L44, mitochondrial isoform X2.	0.667
AGO2	PRKRA	A0A2U3ZKX6	A0A2U3W6H7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Interferon-inducible double-stranded RNA-dependent protein kinase activator A.	0.727
AGO2	STAU2	A0A2U3ZKX6	A0A2U3ZJ73	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Double-stranded RNA-binding protein Staufen homolog 2 isoform X1.	0.616
AGO2	TARBP2	A0A2U3ZKX6	A0A2U3WCQ3	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.855
AGO2	TNRC6A	A0A2U3ZKX6	A0A2U3ZF29	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Trinucleotide repeat-containing gene 6A protein.	0.946
AGO2	TNRC6C	A0A2U3ZKX6	A0A2U3VI13	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Trinucleotide repeat-containing gene 6C protein isoform X1.	0.848
DICER1	AGO1	A0A2U3VI99	A0A2U3W3V7	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.860