PAXIP1 protein (Odobenus rosmarus) - STRING interaction network

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Score

PAXIP1

PAX-interacting protein 1. (1034 aa)

Predicted Functional Partners:

RIF1

0.939

TP53BP1

0.910

ATM

0.872

SMC6

0.855

ANKRD32

0.846

NBN

0.837

PAGR1

0.807

LOC101383856

0.789

MRE11A

0.785

KDM6B

0.777

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD32	ATM	A0A2U3X4F2	A0A2U3VZR5	Ankyrin repeat domain-containing protein 32 isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.884
ANKRD32	MRE11A	A0A2U3X4F2	A0A2U3ZTY7	Ankyrin repeat domain-containing protein 32 isoform X1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.851
ANKRD32	NBN	A0A2U3X4F2	A0A2U3ZWT9	Ankyrin repeat domain-containing protein 32 isoform X1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.910
ANKRD32	PAXIP1	A0A2U3X4F2	A0A2U3W5X9	Ankyrin repeat domain-containing protein 32 isoform X1.	PAX-interacting protein 1.	0.846
ANKRD32	SMC6	A0A2U3X4F2	A0A2U3WFG6	Ankyrin repeat domain-containing protein 32 isoform X1.	Structural maintenance of chromosomes protein 6.	0.519
ANKRD32	TP53BP1	A0A2U3X4F2	A0A2U3WQI2	Ankyrin repeat domain-containing protein 32 isoform X1.	Tumor suppressor p53-binding protein 1.	0.894
ATM	ANKRD32	A0A2U3VZR5	A0A2U3X4F2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ankyrin repeat domain-containing protein 32 isoform X1.	0.884
ATM	MRE11A	A0A2U3VZR5	A0A2U3ZTY7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.998
ATM	NBN	A0A2U3VZR5	A0A2U3ZWT9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.997
ATM	PAXIP1	A0A2U3VZR5	A0A2U3W5X9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX-interacting protein 1.	0.872
ATM	RIF1	A0A2U3VZR5	A0A2U3X063	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere-associated protein RIF1 isoform X1.	0.842
ATM	TP53BP1	A0A2U3VZR5	A0A2U3WQI2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor suppressor p53-binding protein 1.	0.953
KDM6B	PAGR1	A0A2U3VT90	A0A2U3VQ03	Lysine-specific demethylase 6B isoform X1.	PAXIP1-associated glutamate-rich protein 1.	0.692
KDM6B	PAXIP1	A0A2U3VT90	A0A2U3W5X9	Lysine-specific demethylase 6B isoform X1.	PAX-interacting protein 1.	0.777
LOC101383856	PAGR1	A0A2U3X4H3	A0A2U3VQ03	Lysine-specific demethylase 6A isoform X1.	PAXIP1-associated glutamate-rich protein 1.	0.799
LOC101383856	PAXIP1	A0A2U3X4H3	A0A2U3W5X9	Lysine-specific demethylase 6A isoform X1.	PAX-interacting protein 1.	0.789
MRE11A	ANKRD32	A0A2U3ZTY7	A0A2U3X4F2	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Ankyrin repeat domain-containing protein 32 isoform X1.	0.851
MRE11A	ATM	A0A2U3ZTY7	A0A2U3VZR5	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
MRE11A	NBN	A0A2U3ZTY7	A0A2U3ZWT9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.999
MRE11A	PAXIP1	A0A2U3ZTY7	A0A2U3W5X9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	PAX-interacting protein 1.	0.785